Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans
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The purpose of this study, is to study the uptake of the pharmaceutical antifungal miconazole when used as a vaginal suppository in young women. The investigators want to know if the uptake is big enough to cause a biological effect (effect on CYP1A2 and CYP3A4 activity).
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Age 18-45 years
Written authority to the GCP-unit
Hypersensitivity to miconazole
Hypersensitivity to sodium ethyl parahydroxybenzoic acid(E219)
Hypersensitivity to sodium propyl parahydroxybenzoic acid (E217)
Using contraceptives with hormones
Daily consumption of alcohol
Daily use of medicine
Participated in a clinical trial within the last 3 months