Antioxidant Systems and Age-Related Macular Degeneration
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|ClinicalTrials.gov Identifier: NCT00668213|
Recruitment Status : Completed
First Posted : April 29, 2008
Last Update Posted : January 10, 2014
The objective of this study was to determine whether the antioxidant supplements used in AREDS shifted the plasma pool of the AREDS subjects to a more reduced state. The AREDS subjects were randomly assigned to one of four treatment groups:
- antioxidants (500mg Vitamin C, 4000IU Vitamin E, 15mg beta carotene)
- zinc (80mg zinc oxide, 2mg cupric oxide)
- antioxidants plus zinc;
None of the subjects received supplemental GSH or cyst (e) ine.
Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in elderly Americans, with an estimated 15 million people having some form of this disease. AMD primarily affects the central vision and many patients develop severe visual handicaps.
Currently there are no clear established understandings of the etiology or pathogenesis of this disease.
|Condition or disease|
- Age 55-80
- 70 Participants with Intermediate or Advanced AMD
- 70 participants with no ocular signs of AMD
- Willing to give written informed consent, make the required study visits, and follow instructions
- Any race and either sex
- Current history of a medical condition that would preclude scheduled study visits or completion of the study (e.g., unstable cardiovascular disease, unstable pulmonary disease, chronic hepatitis, or AIDS).
- Current or history of an ophthalmic disease in the study eye (other than AMD) that would likely compromise or during follow-up could likely compromise the visual acuity of the study eye (e.g., amblyopia, uncontrolled glaucoma with an IOP > 30mmHg, ischemic optic neuropathy, proliferative diabetic retinopathy, clinically relevant nonproliferative diabetic retinopathy, clinically relevant diabetic macular edema, significant active uveitis).
- Clinical signs of myopic retinopathy, or a refraction of > -8 diopter power in current prescription
- Aphakic or psuedophakic patients may be enrolled if there is no funduscopic evidence of degenerative myopia present and if there is no medical history prior to the patient's cataract surgery of either myopic retinopathy or a refraction of > -8 diopters.
- Intraocular surgery in study eye (eye to be treated) within 60 days prior to enrollment
- Presence of a scleral buckle in the study eye
- Currently participating or has participated in a clinical trial that utilized an investigational drug or treatment within 30 days prior to administration of study medication. Daily vitamins and/or mineral therapy are allowed.
- Known medical history of allergy or sensitivity to any component of the drug formulation and/or fluorescein dye that is clinically significant in the investigator's opinion.
- Patient is on oral anticoagulant therapy of Coumadin
|Study Type :||Observational|
|Actual Enrollment :||143 participants|
|Official Title:||Antioxidant Systems and Age-Related Macular Degeneration|
|Study Start Date :||June 2006|
|Actual Primary Completion Date :||June 2010|
|Actual Study Completion Date :||June 2010|
- The purpose of this study is to find out if there are changes in the blood that would make you at risk for having age related macular degeneration. [ Time Frame: 5 years ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00668213
|United States, Tennessee|
|Vanderbilt Eye Institute|
|Nashville, Tennessee, United States, 37232-8808|
|Principal Investigator:||Paul Sternberg, MD||Vanderbilt University Medical Center|