Working… Menu

Psychotherapy for Intermittent Explosive Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00667212
Recruitment Status : Completed
First Posted : April 28, 2008
Last Update Posted : June 13, 2013
Information provided by (Responsible Party):
University of Chicago

Brief Summary:
The goal of this study is to examine the effectiveness two forms of psychotherapy (also known as "talk therapy" ) for individuals with anger and aggression problems. Anger and aggression are everywhere - on the road, in the schools, at little league games, at home, and at work. In this study we are testing usefulness of anger management techniques in reducing symptoms of Intermittent Explosive Disorder (IED) and impulsive, aggressive behavior.

Condition or disease Intervention/treatment Phase
Anger Intermittent Explosive Disorder Behavioral: Cognitive Behavioral Therapy Behavioral: Supportive Psychotherapy Phase 2

Detailed Description:

Qualified participants will be randomly assigned to 12 1-hour sessions of either cognitive-behavioral therapy or supportive psychotherapy.

Participation in this study will require 16 visits over approximately 4 months with 3 follow-up sessions over a 12 month period. Therapy is provided at no cost and each study participant will receive a comprehensive psychological assessment. Two types of talk therapy are being offered in this study. One form of therapy focuses on thought and behaviors associated with anger and aggression. This type of therapy is known as cognitive behavioral therapy. The other type of therapy focuses on the individuals' feeling about their anger /aggression and the situations that lead to this anger. This is known as supportive therapy. The form of therapy you are given will be randomly determined (like by flipping of a coin).

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Individual Cognitive Behavioral Psychotherapy for Intermittent Explosive Disorder
Study Start Date : August 2006
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Arm Intervention/treatment
Active Comparator: 2
Supportive Psychotherapy
Behavioral: Supportive Psychotherapy
Twelve weekly therapy sessions, approximately one hour each in duration

Active Comparator: 1
Cognitive Behavioral Therapy (Cognitive Restructuring, Relaxation, and Coping Skills Training: CRCST)
Behavioral: Cognitive Behavioral Therapy
Twelve weekly therapy sessions, approximately one hour each in duration
Other Name: Cognitive Restructuring, Relaxation, and Coping Skills Training

Primary Outcome Measures :
  1. Overt Aggression Scale - Modified (OASM) [ Time Frame: Screen Visit, Pre-Therapy visit, Therapy sessions 2, 4, 6, 8, 12, Post-Therapy Visit, 3, 6, and 12-month Follow-Up Vists ]
  2. State-Trait Anger Expression Inventory - Trait Anger Scale [STAXI-T] [ Time Frame: Pre-Therapy visit, Therapy session 7, Post-Therapy visit ]
  3. Intermittent Explosive Disorder Interview [ Time Frame: Diagnostic Interview, Post-Therapy Visit (Modified), 3, 6, and 12-month Follow-Up vists (modified) ]

Secondary Outcome Measures :
  1. Behavioral aggression measures (Taylor Aggression Paradigm [TAP], Point Subtraction Aggression Paradigm [PSAP]) [ Time Frame: Pre-Therapy Visit, Post-Therapy Visit, 3, 6, and 12-month Follow-Up visits ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Have problems with anger, temper outbursts, being irritable, getting in trouble at work or at home because of impulsive/aggressive behavior.
  • Between the ages of 18 and 55.
  • Meet other eligibility requirements as outlined by the research protocol.

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00667212

Layout table for location information
United States, Illinois
University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Layout table for investigator information
Principal Investigator: Michael McCloskey, PhD University of Chicago

Layout table for additonal information
Responsible Party: University of Chicago Identifier: NCT00667212     History of Changes
Other Study ID Numbers: 15143A
First Posted: April 28, 2008    Key Record Dates
Last Update Posted: June 13, 2013
Last Verified: December 2010
Keywords provided by University of Chicago:
Additional relevant MeSH terms:
Layout table for MeSH terms
Disruptive, Impulse Control, and Conduct Disorders
Pathologic Processes
Mental Disorders