Bronchospasm Associated With High Nitric Oxide

This study has been completed.
Information provided by:
University of Sao Paulo Identifier:
First received: April 23, 2008
Last updated: NA
Last verified: April 2008
History: No changes posted
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Airway Hyperresponsiveness

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm

Resource links provided by NLM:

Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • Exhaled nitric oxide in parts per billion [ Time Frame: one to six months after surgery ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Eosinophils concentration within sputum sample, pulmonary function tests [ Time Frame: one to six months after surgery ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Enrollment: 31
Study Start Date: January 1999
Study Completion Date: December 2004
Patients who presented bronchospasm during anesthesia induction
Patients who presented bronchospasm during anesthesia induction and were identified as asthmatics
Patients who were submitted to anesthesia induction and showed no complications

Detailed Description:
Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Ages Eligible for Study:   16 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Hospital, late post-anesthesia cared patients

Inclusion Criteria:

  • patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion Criteria:

  • hypertension, COPD, diabetes, pregnancy
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Please refer to this study by its identifier: NCT00666510

Hospital das Clínicas da FMUSP
São Paulo, Brazil, 05430 010
Sponsors and Collaborators
University of Sao Paulo
Principal Investigator: Joaquim E Vieira, MD, PhD University of Sao Paulo Medical School - FMUSP
  More Information

Responsible Party: Joaquim Edson Vieira, Fisiopatologia Experimental FMUSP Identifier: NCT00666510     History of Changes
Other Study ID Numbers: CAP125-01 
Study First Received: April 23, 2008
Last Updated: April 23, 2008
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by University of Sao Paulo:
nitric oxide
induced sputum

Additional relevant MeSH terms:
Bronchial Spasm
Respiratory Hypersensitivity
Bronchial Diseases
Hypersensitivity, Immediate
Immune System Diseases
Respiratory Tract Diseases
Nitric Oxide
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Endothelium-Dependent Relaxing Factors
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Protective Agents
Respiratory System Agents
Vasodilator Agents processed this record on May 26, 2016