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Joint Stiffness Following Knee Replacement Surgery

This study has been withdrawn prior to enrollment.
Information provided by (Responsible Party):
Dr. Guy Trudel, Ottawa Hospital Research Institute Identifier:
First received: April 21, 2008
Last updated: April 22, 2015
Last verified: April 2015
Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.

Joint Contracture

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Capsular Changes in Joint Contractures Post-Knee Arthroplasty:A Case-Control Study

Resource links provided by NLM:

Further study details as provided by Ottawa Hospital Research Institute:

Primary Outcome Measures:
  • Gene expression [ Time Frame: Dec 2015 ]

Enrollment: 0
Study Start Date: December 2006
Study Completion Date: April 2015
Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Detailed Description:
After total knee replacement surgery, some people develop joint stiffness, which is also called a joint contracture. Contractures cause the envelope of the knee (called the capsule) to stiffen and become rigid so the patient can no longer move their knee the way they used to. After stretching and other exercises, only a surgery can try and divide or remove the contracture. The main purpose of this research is to study the cause of the contracture and specifically if certain people are predisposed to contractures.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
joint contractures following knee surgery

Inclusion Criteria:

-knee contractures post arthroplasty scheduled for arthrotomy with debridement of capsular tissue Controls will be patients scheduled for arthrotomy with debridement of capsular tissue for the other reasons(primary knee arthroplasty, ORIF of the knee secondary to trauma, ACL repair, amputation, elective joint arthroplasty with capsuloplasty etc.)


  • transmissible disease (HIV, Hep B,C)
  • confirmed or suspected neoplasia
  • suspected infection
  Contacts and Locations
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Please refer to this study by its identifier: NCT00664651

Canada, Ontario
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1Y 4E9
Sponsors and Collaborators
Ottawa Hospital Research Institute
Principal Investigator: Guy Trudel, MD,MSc,FRCPC OHRI / The Ottawa Hospital
  More Information

Responsible Party: Dr. Guy Trudel, Researcher, Ottawa Hospital Research Institute Identifier: NCT00664651     History of Changes
Other Study ID Numbers: 2006541
Study First Received: April 21, 2008
Last Updated: April 22, 2015

Keywords provided by Ottawa Hospital Research Institute:
joint contracture
total knee arthroplasty

Additional relevant MeSH terms:
Joint Diseases
Musculoskeletal Diseases
Muscular Diseases processed this record on May 23, 2017