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Joint Stiffness Following Knee Replacement Surgery

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ClinicalTrials.gov Identifier: NCT00664651
Recruitment Status : Withdrawn
First Posted : April 23, 2008
Last Update Posted : April 23, 2015
Sponsor:
Information provided by (Responsible Party):
Dr. Guy Trudel, Ottawa Hospital Research Institute

Brief Summary:
Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.

Condition or disease
Joint Contracture

Detailed Description:
After total knee replacement surgery, some people develop joint stiffness, which is also called a joint contracture. Contractures cause the envelope of the knee (called the capsule) to stiffen and become rigid so the patient can no longer move their knee the way they used to. After stretching and other exercises, only a surgery can try and divide or remove the contracture. The main purpose of this research is to study the cause of the contracture and specifically if certain people are predisposed to contractures.

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Capsular Changes in Joint Contractures Post-Knee Arthroplasty:A Case-Control Study
Study Start Date : December 2006
Actual Primary Completion Date : April 2015
Actual Study Completion Date : April 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Knee Replacement




Primary Outcome Measures :
  1. Gene expression [ Time Frame: Dec 2015 ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
joint contractures following knee surgery
Criteria

Inclusion Criteria:

-knee contractures post arthroplasty scheduled for arthrotomy with debridement of capsular tissue Controls will be patients scheduled for arthrotomy with debridement of capsular tissue for the other reasons(primary knee arthroplasty, ORIF of the knee secondary to trauma, ACL repair, amputation, elective joint arthroplasty with capsuloplasty etc.)

Exclusion:

  • transmissible disease (HIV, Hep B,C)
  • confirmed or suspected neoplasia
  • suspected infection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00664651


Locations
Canada, Ontario
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1Y 4E9
Sponsors and Collaborators
Ottawa Hospital Research Institute
Investigators
Principal Investigator: Guy Trudel, MD,MSc,FRCPC OHRI / The Ottawa Hospital

Responsible Party: Dr. Guy Trudel, Researcher, Ottawa Hospital Research Institute
ClinicalTrials.gov Identifier: NCT00664651     History of Changes
Other Study ID Numbers: 2006541
First Posted: April 23, 2008    Key Record Dates
Last Update Posted: April 23, 2015
Last Verified: April 2015

Keywords provided by Dr. Guy Trudel, Ottawa Hospital Research Institute:
joint contracture
total knee arthroplasty

Additional relevant MeSH terms:
Contracture
Joint Diseases
Musculoskeletal Diseases
Muscular Diseases