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Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00664300
First Posted: April 22, 2008
Last Update Posted: January 19, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Clermont-Ferrand
  Purpose

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).


Condition Intervention
Gilles de la Tourette's Syndrome Behavioral: Facial expression recognition of emotion

Study Type: Observational
Official Title: Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

Resource links provided by NLM:


Further study details as provided by University Hospital, Clermont-Ferrand:

Primary Outcome Measures:
  • Facial expression recognition test [ Time Frame: % of exact responses ]

Secondary Outcome Measures:
  • Lexical decision test [ Time Frame: The time to respond ]

Estimated Enrollment: 60
Study Start Date: August 2007
Study Completion Date: October 2009
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
2
One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers
Behavioral: Facial expression recognition of emotion
Facial expression recognition test Lexical decision test

Detailed Description:

20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
30 patients with Gilles de la Tourette's Syndrome and 30 healthy paired volunteers (control group)
Criteria

Inclusion Criteria:

  • Age : >18 years
  • Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
  • Stability of treatment >1 month
  • Mini Mental State > 26
  • Affiliation to social security
  • Agreement of patients

Exclusion Criteria:

  • Patients with cognitive disorders, dementia, mental retardation…
  • Patients with serious neurological pathologies
  • Patients with a vision contrast altered.
  • Patients who do not understand the words associated with an emotion
  • Pregnant women
  • Person who participate to an other study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00664300


Locations
France
CHU
Clermont-Ferrand, France, 63003
Sponsors and Collaborators
University Hospital, Clermont-Ferrand
Investigators
Principal Investigator: Isabelle Jalenques, PUPH University Hospital, Clermont-Ferrand
  More Information

Responsible Party: Pr Jalenques, CHU Clermont-Ferrand
ClinicalTrials.gov Identifier: NCT00664300     History of Changes
Other Study ID Numbers: CHU-0032
RBHP 2007 Jalenques
First Submitted: April 21, 2008
First Posted: April 22, 2008
Last Update Posted: January 19, 2011
Last Verified: January 2011

Keywords provided by University Hospital, Clermont-Ferrand:
Gilles de la Tourette's syndrome
Facial expression recognition of emotion
Frequency levels
Automatic and voluntary information treatment
Patient with Gilles de la Tourette's syndrome

Additional relevant MeSH terms:
Syndrome
Tourette Syndrome
Disease
Pathologic Processes
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tic Disorders
Movement Disorders
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn
Neurodevelopmental Disorders
Mental Disorders