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Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

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ClinicalTrials.gov Identifier: NCT00664300
Recruitment Status : Completed
First Posted : April 22, 2008
Last Update Posted : January 19, 2011
Sponsor:
Information provided by:
University Hospital, Clermont-Ferrand

Brief Summary:

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).


Condition or disease Intervention/treatment
Gilles de la Tourette's Syndrome Behavioral: Facial expression recognition of emotion

Detailed Description:

20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test


Study Type : Observational
Estimated Enrollment : 60 participants
Official Title: Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome
Study Start Date : August 2007
Actual Primary Completion Date : October 2008
Actual Study Completion Date : October 2009

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
2
One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers
Behavioral: Facial expression recognition of emotion
Facial expression recognition test Lexical decision test




Primary Outcome Measures :
  1. Facial expression recognition test [ Time Frame: % of exact responses ]

Secondary Outcome Measures :
  1. Lexical decision test [ Time Frame: The time to respond ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
30 patients with Gilles de la Tourette's Syndrome and 30 healthy paired volunteers (control group)
Criteria

Inclusion Criteria:

  • Age : >18 years
  • Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
  • Stability of treatment >1 month
  • Mini Mental State > 26
  • Affiliation to social security
  • Agreement of patients

Exclusion Criteria:

  • Patients with cognitive disorders, dementia, mental retardation…
  • Patients with serious neurological pathologies
  • Patients with a vision contrast altered.
  • Patients who do not understand the words associated with an emotion
  • Pregnant women
  • Person who participate to an other study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00664300


Locations
France
CHU
Clermont-Ferrand, France, 63003
Sponsors and Collaborators
University Hospital, Clermont-Ferrand
Investigators
Principal Investigator: Isabelle Jalenques, PUPH University Hospital, Clermont-Ferrand

Responsible Party: Pr Jalenques, CHU Clermont-Ferrand
ClinicalTrials.gov Identifier: NCT00664300     History of Changes
Other Study ID Numbers: CHU-0032
RBHP 2007 Jalenques
First Posted: April 22, 2008    Key Record Dates
Last Update Posted: January 19, 2011
Last Verified: January 2011

Keywords provided by University Hospital, Clermont-Ferrand:
Gilles de la Tourette's syndrome
Facial expression recognition of emotion
Frequency levels
Automatic and voluntary information treatment
Patient with Gilles de la Tourette's syndrome

Additional relevant MeSH terms:
Syndrome
Tourette Syndrome
Disease
Pathologic Processes
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tic Disorders
Movement Disorders
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn
Neurodevelopmental Disorders
Mental Disorders