Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00664222
Recruitment Status : Completed
First Posted : April 22, 2008
Last Update Posted : April 22, 2008
Information provided by:
Tottori University Hospital

Brief Summary:
The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Condition or disease Intervention/treatment Phase
Chronic Stable Heart Failure Drug: spironolactone + furosemide Phase 4

Detailed Description:
Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Spironolactone on Insulin Resistance in Patients With Chronic Heart Failure
Study Start Date : January 2004
Estimated Study Completion Date : December 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure
U.S. FDA Resources

Intervention Details:
    Drug: spironolactone + furosemide
    spironolactone 25mg/day, 16 weeks and furosemide 20mg/day, 16weeks

Primary Outcome Measures :
  1. insulin resistance [ Time Frame: 16 weeks ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All

Inclusion Criteria:

  • chronic stable heart failure

Exclusion Criteria:

  • renal dysfunction or under treatment with antidiabetic agents

Responsible Party: Kazuhide Ogino, MD, Center for Clinical Residency Program, Tottori University Hospital Identifier: NCT00664222     History of Changes
Other Study ID Numbers: #344.1
First Posted: April 22, 2008    Key Record Dates
Last Update Posted: April 22, 2008
Last Verified: April 2008

Keywords provided by Tottori University Hospital:
heart failure
insulin resistance
inflammatory cytokine

Additional relevant MeSH terms:
Heart Failure
Insulin Resistance
Heart Diseases
Cardiovascular Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Hypoglycemic Agents
Physiological Effects of Drugs
Natriuretic Agents
Sodium Potassium Chloride Symporter Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Mineralocorticoid Receptor Antagonists
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Diuretics, Potassium Sparing