Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus
Parkinson'disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists usually leads to a dramatic improvement of symptoms, but disease progression nevertheless remains inevitable. Bilateral Deep brain stimulation in subthalamic nucleus is now considered the gold standard surgical treatment.
Parkinson'disease mainly affects the nigrostriatal dopaminergic system which is linked to the limbic system and could be responsible of a specific trouble in the recognition in some facial expression.
We hypothesise that patients with Parkinson'disease present a dysfunction of voluntary and automatic treatment of emotional information.
The main purpose of this study is to show if patients with Parkinson'disease present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).
We also examine the role of L-Dopa and the deep brain stimulation on emotion perception
|Idiopathic Parkinson's Disease||Behavioral: Facial expression recognition of emotion|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus .|
- Facial expression recognition test [ Time Frame: % of exact responses ]
- Lexical decision test [ Time Frame: The time to respond ]
|Study Start Date:||September 2007|
|Study Completion Date:||October 2009|
|Primary Completion Date:||October 2008 (Final data collection date for primary outcome measure)|
40 patients with an idiopathic Parkinson's disease and 40 healthy paired volunteers (control group)
Behavioral: Facial expression recognition of emotion
Facial expression recognition test Lexical decisiontestBehavioral: Facial expression recognition of emotion
Facial expression recognition test Lexical decision test
40 patients with an Idiopathic Parkinson's disease divided in two groups :
- 20 patients evaluated before surgery and 6 month after surgery
20 patients only evaluated after surgery.
40 paired healthy volunteers
1) Study progress (patients):
Inclusion visit :
Neurological evaluations .
Neuropsychological evaluations : MMS, MADRS, MATTIS, BREF, Wisconsin test, Apathy test, Benton….
Ophthalmic visit : VISTECH
- for patients evaluated before surgery Facial expression recognition test Lexical decision test Made in two conditions : without the treatment (Med OFF) and one hour after the L-Dopa administration (MED ON)
for patients evaluated after surgery Facial expression recognition test Lexical decision test Made in four conditions
- Without stimulation (STIM OFF) and medication (MED OFF)
- MED OFF and STIM ON
- MED ON and STIM OFF
MED ON and STIM ON
2) Study progress (healthy volunteers): Ophthalmic visit MMS Facial expression recognition test Lexical decision test
Please refer to this study by its ClinicalTrials.gov identifier: NCT00664157
|Clermont-Ferrand, France, 63003|
|Principal Investigator:||Franck Durif, PUPH||University Hospital, Clermont-Ferrand|