Matrix Metalloproteinase (MMP) in Heart Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00663494
Recruitment Status : Completed
First Posted : April 22, 2008
Last Update Posted : July 21, 2011
Information provided by:
Tottori University Hospital

Brief Summary:
The purpose of this study is to evaluate the production of MMP in failing hearts.

Condition or disease
Chronic Stable Heart Failure

Detailed Description:
Myocardial fibrosis is observed in failing hearts and parallel to the progression of chronic heart failure (CHF) and myocardial remodeling. Matrix metalloproteinases (MMPs) are considered markers of fibrosis. Recently, circulating MMPs can be measured and are elevated in patients with CHF. However, MMPs it is still unclear whether MMPs are produced in failing hearts. Thus, the purpose of this study is to evaluate the production of MMP in failing hearts.

Study Type : Observational
Estimated Enrollment : 22 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: MMP is Produced in Failing Hearts
Study Start Date : February 2003
Actual Study Completion Date : July 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure
U.S. FDA Resources

Primary Outcome Measures :
  1. MMPs level of coronary sinus

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
chronic heart failure

Inclusion Criteria:

  • chronic stable heart failure

Responsible Party: Kazuhide Ogino, Tottori University Hospital Identifier: NCT00663494     History of Changes
Other Study ID Numbers: #244
First Posted: April 22, 2008    Key Record Dates
Last Update Posted: July 21, 2011
Last Verified: April 2008

Keywords provided by Tottori University Hospital:
heart failure
coronary sinus

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases