Matrix Metalloproteinase (MMP) in Heart Failure

This study has been completed.
Information provided by:
Tottori University Hospital Identifier:
First received: April 18, 2008
Last updated: July 20, 2011
Last verified: April 2008
The purpose of this study is to evaluate the production of MMP in failing hearts.

Chronic Stable Heart Failure

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: MMP is Produced in Failing Hearts

Resource links provided by NLM:

Further study details as provided by Tottori University Hospital:

Primary Outcome Measures:
  • MMPs level of coronary sinus

Estimated Enrollment: 22
Study Start Date: February 2003
Study Completion Date: July 2006
Detailed Description:
Myocardial fibrosis is observed in failing hearts and parallel to the progression of chronic heart failure (CHF) and myocardial remodeling. Matrix metalloproteinases (MMPs) are considered markers of fibrosis. Recently, circulating MMPs can be measured and are elevated in patients with CHF. However, MMPs it is still unclear whether MMPs are produced in failing hearts. Thus, the purpose of this study is to evaluate the production of MMP in failing hearts.

Genders Eligible for Study:   Both
Sampling Method:   Non-Probability Sample
Study Population
chronic heart failure

Inclusion Criteria:

  • chronic stable heart failure
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  More Information

No publications provided

Responsible Party: Kazuhide Ogino, Tottori University Hospital Identifier: NCT00663494     History of Changes
Other Study ID Numbers: #244 
Study First Received: April 18, 2008
Last Updated: July 20, 2011
Health Authority: Japan: Ministry of Health, Labor and Welfare

Keywords provided by Tottori University Hospital:
heart failure
coronary sinus

Additional relevant MeSH terms:
Heart Failure
Cardiovascular Diseases
Heart Diseases processed this record on February 11, 2016