Consequences of Hypoglycemia on Intensive Care Unit (ICU) Patients

This study has been completed.
Information provided by:
University Hospital Muenster Identifier:
First received: April 16, 2008
Last updated: January 8, 2010
Last verified: January 2010

Hypoglycemia occurs frequently during intensive blood glucose control in critically ill patients. The incidence of hypoglycaemia is associated with impaired outcome. However, it is hitherto unknown if hypoglycaemia itself predisposes patients to neurological impairment, e.g. cognitive dysfunction, or if it is the underlying medical condition that makes the patient prone to a high risk of hypoglycaemia and, concomitantly, neurocognitive impairment. Therefore we investigate neurocognitive function in patients who had hypoglycemias during their intensive care stay and compare the results to patients without hypoglycaemia whose medical conditions are matched to the hypoglycaemia patients.

Critical Illness

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Does Hypoglycemia Under Intensive Insulin Therapy During Critical Illness Lead to Neurocognitive Dysfunction

Resource links provided by NLM:

Further study details as provided by University Hospital Muenster:

Primary Outcome Measures:
  • neurocognitive function [ Time Frame: 1 year after ICU discharge ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • neurocognitive function [ Time Frame: 2,3, and 4 years after ICU discharge ] [ Designated as safety issue: No ]

Enrollment: 74
Study Start Date: April 2008
Study Completion Date: September 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
patients with hypoglycemia during intensive care
patients without hypoglycemia during intensive care


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

All patients who were admitted to the hospital ICU after 2003 are screened for hypoglycemia


Inclusion Criteria:

  • all patients

Exclusion Criteria:

  • clinical diagnosis of diabetes mellitus
  • brain injury of any kind prior to or upon ICU-admission
  • pre-existing mental or psychiatric disorder
  • terminal kidney or liver failure prior admission
  • drug abuse,
  • CPR > 5 min
  • HIV
  • Lues
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Please refer to this study by its identifier: NCT00662922

Department of Anesthesiology and Intensive Care, University Hospital Münster
Münster, Germany, D-48149
Sponsors and Collaborators
University Hospital Muenster
Principal Investigator: Björn Ellger, MD Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster
  More Information

Responsible Party: Principle investigator, Dr. Björn Ellger, Department of Anesthesiology and Intensive Care Medicine Identifier: NCT00662922     History of Changes
Other Study ID Numbers: 05-AnIt-07
Study First Received: April 16, 2008
Last Updated: January 8, 2010
Health Authority: Germany: Ethics Commission

Keywords provided by University Hospital Muenster:
critical illness
neurocognitive dysfunction
intensive insulin therapy

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Glucose Metabolism Disorders
Metabolic Diseases
Pathologic Processes processed this record on October 09, 2015