Optimizing Drug-Therapy in Patients 80 Years and Older
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|ClinicalTrials.gov Identifier: NCT00661310|
Recruitment Status : Completed
First Posted : April 18, 2008
Last Update Posted : December 5, 2008
|Condition or disease||Intervention/treatment||Phase|
|Drug-Related Problems||Other: Drug review 80+ -To reduce usage of hospital care||Not Applicable|
Optimising drug-therapy for patients, 80 years and older, to reduce hospital visits
Background and Objective:
Results from a pilot-study performed in 2004 at the Academic Hospital, Uppsala, including 214 consecutive patients (80 years old or older) showed that 9.4%-13.6% of the patients were acutely admitted to hospital due to a drug related problem1. Other similar international studies show that the frequency of drug-related hospital admissions stands for at least 14% of the acute admissions (14%-30.4%). Of these admissions it was estimated that 32%-69% were preventable 2,3,4.
A study from Antrim Hospital, Northern Ireland, showed that pharmacists´ involvement in the health care team can reduce the number of acute hospital admissions and improve quality of drug use5.
In view of these findings this study was initiated in 2005 with fundings from the Drug and Therapeutics committee, the County Council of Uppsala, the Division of Acute-Medicine and the Pharmacy Department at the Academic Hospital in Uppsala
Aim and objectives:
The Study Aim was to optimize drug-prescribing and drug use for patients 80 years and older.
The main objective was to reduce the number of hospital visits for patients 80-years old or older.
A randomized, controlled trial including 400 patients (200+200). Patients in the intervention group (I) received a patient interview on admission, drug counseling on discharge and a drug review - all performed by a clinical pharmacist. Patients in the control group (C) received standard care, without pharmacists´ involvement.
Patients were included between Oct 2005 and June 2006.
Two wards at the Division of Acute-Medicine at Uppsala University Hospital, Sweden
Main Outcome Measures:
1) Frequency of hospital visits 12 months after (last included patient) discharge from hospital for (I) and (C).
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||400 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Health Services Research|
|Official Title:||Optimizing Drug-Therapy in Patients, 80 Years and Older, in Order to Reduce Drug-Related Morbidity and Usage of Secondary Care - a Randomized Controlled Trial|
|Study Start Date :||September 2005|
|Actual Primary Completion Date :||June 2006|
|Actual Study Completion Date :||June 2007|
Intervention by team consisting of Doctor, pharmacist and nurse
Other: Drug review 80+ -To reduce usage of hospital care
drug review performed by multiprofessional team, including clinical pharmacist, in order to optimize drug therapy and reduce usage of hospital care. Also patient education and follow-up
|No Intervention: C|
- Effects on hospital visits [ Time Frame: 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00661310
|Uppsala University hospital|
|Uppsala, Sweden, 75185|
|Principal Investigator:||Henrik Toss, MD PhD||Uppsala University Hospital|