Is Pentoxifylline Able to Improve Olfactory Sensitivity?
Recruitment status was Recruiting
Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Agapurin Retard Used in Patients With Smell Disorder- A Post-marketing Observational Study|
- TDI-score [ Time Frame: at day 0 and follow up after 3 weeks ] [ Designated as safety issue: No ]
- odor threshold odor discrimination odor identification [ Time Frame: at day 0 and at follow up after 3 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||November 2009|
|Estimated Study Completion Date:||November 2012|
|Estimated Primary Completion Date:||November 2011 (Final data collection date for primary outcome measure)|
Patients with posttraumatic, idiopathic, and postinflammatory cause of smell loss; patients age between 18 and 50 years. Odor threshold better than 1.
Drug: Pentoxifylline retard 400mg
Agapurin retard 400mg 3/day per os for 3 weeks
Other Name: Agapurin retard
Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00660868
|Contact: Volker Gudziol, Dr. firstname.lastname@example.org|
|Contact: Thomas Hummel, Prof. Dr.||email@example.com|
|Zentrum für Riechen und Schmecken, Universitäts- HNO- Klinik Dresden||Recruiting|
|Dresden, Germany, 01307|
|Contact: Thomas Hummel, Prof. Dr. 49-351-458-4189 firstname.lastname@example.org|
|Principal Investigator: Volker Gudziol, Dr. med.|
|Sub-Investigator: Thomas Hummel, Prof. Dr.|
|Principal Investigator:||Volker Gudziol, Dr. med.||Technische Universität Dresden|