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Endothelial Dysfunction Induced by Postprandial Lipemia

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ClinicalTrials.gov Identifier: NCT00660491
Recruitment Status : Completed
First Posted : April 17, 2008
Last Update Posted : January 6, 2012
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).


Condition or disease Intervention/treatment Phase
Healthy Subjects Other: exercise training Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 8 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise
Study Start Date : January 2008
Actual Primary Completion Date : September 2008
Actual Study Completion Date : October 2008

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
No Intervention: 1
Control
No Intervention: 2
moderate exercise training group
Experimental: 3
high intensity exercise group
Other: exercise training
moderate intensity exercise group, and high intensity exercise group




Primary Outcome Measures :
  1. Flow mediated dilatation [ Time Frame: baseline, post exercise, 30min, 2hour, 4hour post exercise ]

Secondary Outcome Measures :
  1. blood lipid profile [ Time Frame: same as flow mediated dilatation ]


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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion Criteria:

  • unstable angina, CHD, heart failure,

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00660491


Locations
Norway
NTNU
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Study Chair: Ulrik Wisloff, Professor NTNU

Publications of Results:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00660491     History of Changes
Other Study ID Numbers: Exercise, Food and Endothelium
First Posted: April 17, 2008    Key Record Dates
Last Update Posted: January 6, 2012
Last Verified: January 2012

Keywords provided by Norwegian University of Science and Technology:
flow mediated dilatation
maximal oxygen uptake
blood lipid