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Endothelial Dysfunction Induced by Postprandial Lipemia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00660491
First Posted: April 17, 2008
Last Update Posted: January 6, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Norwegian University of Science and Technology
  Purpose

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).


Condition Intervention Phase
Healthy Subjects Other: exercise training Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Flow mediated dilatation [ Time Frame: baseline, post exercise, 30min, 2hour, 4hour post exercise ]

Secondary Outcome Measures:
  • blood lipid profile [ Time Frame: same as flow mediated dilatation ]

Enrollment: 8
Study Start Date: January 2008
Study Completion Date: October 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: 1
Control
No Intervention: 2
moderate exercise training group
Experimental: 3
high intensity exercise group
Other: exercise training
moderate intensity exercise group, and high intensity exercise group

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion Criteria:

  • unstable angina, CHD, heart failure,
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00660491


Locations
Norway
NTNU
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Study Chair: Ulrik Wisloff, Professor NTNU
  More Information

Publications:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00660491     History of Changes
Other Study ID Numbers: Exercise, Food and Endothelium
First Submitted: April 15, 2008
First Posted: April 17, 2008
Last Update Posted: January 6, 2012
Last Verified: January 2012

Keywords provided by Norwegian University of Science and Technology:
flow mediated dilatation
maximal oxygen uptake
blood lipid