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Endothelial Dysfunction Induced by Postprandial Lipemia

This study has been completed.
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: April 15, 2008
Last updated: January 5, 2012
Last verified: January 2012

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Condition Intervention Phase
Healthy Subjects
Other: exercise training
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise

Resource links provided by NLM:

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Flow mediated dilatation [ Time Frame: baseline, post exercise, 30min, 2hour, 4hour post exercise ]

Secondary Outcome Measures:
  • blood lipid profile [ Time Frame: same as flow mediated dilatation ]

Enrollment: 8
Study Start Date: January 2008
Study Completion Date: October 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: 1
No Intervention: 2
moderate exercise training group
Experimental: 3
high intensity exercise group
Other: exercise training
moderate intensity exercise group, and high intensity exercise group


Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion Criteria:

  • unstable angina, CHD, heart failure,
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Please refer to this study by its identifier: NCT00660491

Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Study Chair: Ulrik Wisloff, Professor NTNU
  More Information

Responsible Party: Norwegian University of Science and Technology Identifier: NCT00660491     History of Changes
Other Study ID Numbers: Exercise, Food and Endothelium
Study First Received: April 15, 2008
Last Updated: January 5, 2012

Keywords provided by Norwegian University of Science and Technology:
flow mediated dilatation
maximal oxygen uptake
blood lipid processed this record on April 28, 2017