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Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by Soroka University Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Soroka University Medical Center Identifier:
First received: April 15, 2008
Last updated: November 9, 2014
Last verified: February 2008
The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .


Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .

Resource links provided by NLM:

Further study details as provided by Soroka University Medical Center:

Estimated Enrollment: 6
Study Start Date: May 2008

Detailed Description:
Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Inclusion Criteria:

  • adults over 18 years old .

Exclusion Criteria:

  • under 18 years old.
  • Artificial pacemaker
  • implantable cardioverter-defibrillator (ICD)
  • Hearing aid, implantable or portable.
  • artificial heart valve
  • Surgical clips
  • Metal fragments in eyes
  • Electronic stimulators
  • Implanted pumps
  • Implantable Neurostimulation Device
  • metal fragments of any sort
  • Permanent makeup or tattoo
  • transfusion pump
  • pregnant or breast feeding women
  • False teeth , retainer or dental crown
  Contacts and Locations
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Please refer to this study by its identifier: NCT00660465

Contact: Alexander Gersten, Ph.D +972-52-3906012

Department of Diagnostic Imaging ;Soroka Univrsity Medical Center Recruiting
Beer Sheva, Israel, 84101
Contact: Ilan Shelef, M.D    +972-8-6403950   
Sub-Investigator: Alexander Gersten, Ph.D         
Sub-Investigator: Batel Lasry         
Sponsors and Collaborators
Soroka University Medical Center
Study Director: Ilan Shelef, M.D Head, Neuroradiolgy Unit ;Department of Diagnostic Imaging ;Soroka Univrsity Medical Center
  More Information

Responsible Party: Alexander Gersten, Ben-Gurion University of the Negev Identifier: NCT00660465     History of Changes
Other Study ID Numbers: SOR467608CTIL
Study First Received: April 15, 2008
Last Updated: November 9, 2014

Keywords provided by Soroka University Medical Center:
Regional BOLD signal dependency on arterial PaCO2.
Effect of breathing exercises on brain regional O2 level.
Healthy subjects

Additional relevant MeSH terms:
Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes processed this record on May 25, 2017