Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement (MyRiAD)

This study has been completed.
Swiss National Science Foundation
Information provided by (Responsible Party):
University of Zurich Identifier:
First received: April 8, 2008
Last updated: May 30, 2012
Last verified: May 2012

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

Myocardial Ischemia
Acute Coronary Syndrome
Myocardial Infarction
Coronary Occlusion
Coronary Thrombosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Study of Myeloid-related Protein 8/14 and Additional Biomarkers (Multi Marker Approach) for Early Diagnosis and Risk Stratification in Patients Presenting With Acute Chest Pain at the Emergency Department

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Diagnosis of acute coronary syndrome [ Time Frame: Emergency room and/or hospital stay ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Incidence of any acute coronary event [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Morbidity from coronary artery disease [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Mortality [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]

Enrollment: 403
Study Start Date: March 2008
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Consecutive patients - systematic sampling - presenting with acute chest pain at the emergency room in which determination of cardiac biomarkers is indicated for clinical diagnostics

Inclusion Criteria:

  • All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion Criteria:

  • Refusal or inability to give informed consent.
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Please refer to this study by its identifier: NCT00657436

Cardiology, University Hospital
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Swiss National Science Foundation
Principal Investigator: Willibald Maier, MD Cardiology, University Hospital Zurich
  More Information

Responsible Party: University of Zurich Identifier: NCT00657436     History of Changes
Other Study ID Numbers: MyRiAD 
Study First Received: April 8, 2008
Last Updated: May 30, 2012
Health Authority: Switzerland: Federal Office of Public Health

Keywords provided by University of Zurich:
Acute Coronary Syndrome
Myocardial Infarction
Coronary Artery Disease

Additional relevant MeSH terms:
Acute Coronary Syndrome
Chest Pain
Coronary Artery Disease
Coronary Occlusion
Coronary Thrombosis
Myocardial Infarction
Myocardial Ischemia
Angina Pectoris
Arterial Occlusive Diseases
Cardiovascular Diseases
Coronary Disease
Embolism and Thrombosis
Heart Diseases
Pathologic Processes
Signs and Symptoms
Vascular Diseases processed this record on May 03, 2016