Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement (MyRiAD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00657436
Recruitment Status : Completed
First Posted : April 14, 2008
Last Update Posted : May 31, 2012
Swiss National Science Foundation
Information provided by (Responsible Party):
University of Zurich

Brief Summary:

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

Condition or disease
Myocardial Ischemia Acute Coronary Syndrome Myocardial Infarction Coronary Occlusion Coronary Thrombosis

Study Type : Observational
Actual Enrollment : 403 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Study of Myeloid-related Protein 8/14 and Additional Biomarkers (Multi Marker Approach) for Early Diagnosis and Risk Stratification in Patients Presenting With Acute Chest Pain at the Emergency Department
Study Start Date : March 2008
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chest Pain

Primary Outcome Measures :
  1. Diagnosis of acute coronary syndrome [ Time Frame: Emergency room and/or hospital stay ]

Secondary Outcome Measures :
  1. Incidence of any acute coronary event [ Time Frame: 1 year ]
  2. Morbidity from coronary artery disease [ Time Frame: 1 year ]
  3. Mortality [ Time Frame: 1 year ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Consecutive patients - systematic sampling - presenting with acute chest pain at the emergency room in which determination of cardiac biomarkers is indicated for clinical diagnostics

Inclusion Criteria:

  • All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion Criteria:

  • Refusal or inability to give informed consent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00657436

Cardiology, University Hospital
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Swiss National Science Foundation
Principal Investigator: Willibald Maier, MD Cardiology, University Hospital Zurich

Responsible Party: University of Zurich Identifier: NCT00657436     History of Changes
Other Study ID Numbers: MyRiAD
First Posted: April 14, 2008    Key Record Dates
Last Update Posted: May 31, 2012
Last Verified: May 2012

Keywords provided by University of Zurich:
Acute Coronary Syndrome
Myocardial Infarction
Coronary Artery Disease

Additional relevant MeSH terms:
Myocardial Infarction
Acute Coronary Syndrome
Myocardial Ischemia
Coronary Artery Disease
Chest Pain
Coronary Occlusion
Coronary Thrombosis
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Disease Attributes
Embolism and Thrombosis
Coronary Disease
Arterial Occlusive Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms