Preemptive Analgesia for Postlaminectomy
|Laminectomy||Drug: Lidocaine, perineural injection, intraoperatively Drug: Lidocaine||Phase 4|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:||Intraoperative Perineural Injection of Lidocaine for Postlaminectomy Pain|
- In the laminectomy operation, right after the exposure of the dorsal root , an injection of lidocaine attenuates postoperative pain. [ Time Frame: postoperative 24 hours ]
|Study Start Date:||September 2007|
|Study Completion Date:||December 2007|
|Primary Completion Date:||November 2007 (Final data collection date for primary outcome measure)|
|Placebo Comparator: A01L||
Drug: Lidocaine, perineural injection, intraoperatively
0.5 cc lidocaine, one single injection over the dorsal root.
Other Name: lidocaineDrug: Lidocaine
0.5 cc %2 lidocaine,single injection
|No Intervention: B01C|
A randomized double-blind 40 patients aged 18-50 of ASA I and II undergoing laminectomy were included in the study. All the patients were followed for their heart rate, arterial pressure , respiratory rate, oxygen saturation, end tidal CO2 and postoperative VAS scores.
All the patients were premedicated with midazolam 0.1 mg/kg intramuscularly 40 minutes prior to surgery. The induction was made 2 mg/kg propofol, 1 ug/kg remifentanyl, 0.5mg/kg rocuronium. After the orotracheal intubation anesthesia was maintained with isoflurane (%0.5-2.0) and 0.1 mg/kg rocuronium.Just before the exposure of dorsal root, 0.5 cc %2 lidocaine was injected on the dorsal root.The patients postoperative analgesic period, VAS scores and additional analgesic need was recorded. For the postoperative analgesia tramadol 1 mg/kg tramadol was used.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00656526
|harran University Education, Research and application hospital|
|Sanliurfa, Turkey, 63000|
|Study Chair:||cengiz Mordeniz, MD, Ass Prof||Harran University|