We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00653809
First Posted: April 7, 2008
Last Update Posted: April 6, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Office of Minority Health
Mississippi Institute for Improvement of Geographic Minority Health
Information provided by (Responsible Party):
Kedra Wallace, University of Mississippi Medical Center
  Purpose
The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Condition
Preeclampsia

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells Co-cultured With Placental Explants From African-american and Caucasian High Risk Pregnancies

Resource links provided by NLM:


Further study details as provided by Kedra Wallace, University of Mississippi Medical Center:

Primary Outcome Measures:
  • Nitric oxide and Endothelin-1 levels [ Time Frame: 48 hours after tissue collection ]

Secondary Outcome Measures:
  • Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome [ Time Frame: within 6 months from tissue collection ]

Biospecimen Retention:   Samples With DNA
Placental Tissue

Enrollment: 52
Study Start Date: June 2007
Study Completion Date: September 2009
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
A, 1, I
Caucasian women without preeclampsia or PIH, delivering their first child
A, 1, II
Caucasian women with preeclampsia or PIH, delivering their first child
A, 2, I
African-american women without preeclampsia or PIH, delivering their first child
A, 2, II
African-American women with preeclampsia or PIH, delivering their first child
B, 1, I
Caucasian women without preeclampsia or PIH, delivering at least their second child
B, 1, II
Caucasian women with preeclampsia or PIH, delivering at least their second child
B, 2, I
African-american women without preeclampsia or PIH, delivering at least their second child
B, 2, II
African-american women with preeclampsia or PIH, delivering at least their second child

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Women delivering babies at the University of MS Medical Center
Criteria

Inclusion Criteria:

  • African-american or Caucasian
  • Pregnant
  • Between ages of 18 - 40 years of age

Exclusion Criteria:

  • Presence of a disease or condition which is not preeclampsia
  • Drug or alcohol abuse during pregnancy
  • Obesity
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00653809


Locations
United States, Mississippi
University of MS Medical Center
Jackson, Mississippi, United States, 39216
Sponsors and Collaborators
University of Mississippi Medical Center
Office of Minority Health
Mississippi Institute for Improvement of Geographic Minority Health
Investigators
Principal Investigator: Kedra L Wallace, PhD Obstetrics & Gynecology
  More Information

Responsible Party: Kedra Wallace, Postdoc Research Fellow, University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT00653809     History of Changes
Other Study ID Numbers: 2007-0065
First Submitted: April 1, 2008
First Posted: April 7, 2008
Last Update Posted: April 6, 2012
Last Verified: April 2012

Additional relevant MeSH terms:
Hypertension, Pregnancy-Induced
Pregnancy Complications
Pre-Eclampsia
Nitric Oxide
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Free Radical Scavengers
Antioxidants
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Vasodilator Agents
Gasotransmitters
Protective Agents