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Use of Multiphoton Microscopy in the Diagnosis of Cancer (MPM)

This study has been completed.
Information provided by (Responsible Party):
Douglas S. Scherr, Weill Medical College of Cornell University Identifier:
First received: March 31, 2008
Last updated: December 8, 2015
Last verified: December 2015
Multiphoton microscopy (MPM) has been shown to be able to image tissue at a cellular level. Our project will initially evaluated the ability of MPM imaging to distinguish normal bladder urothelium from atypical and malignant urothelium in the ex vivo setting. After development of sufficient criteria, we plan to develop an endoscopic bladder probe that will provide a non-invasive means to image the interior of the bladder at the cellular level, which would provide direct evidence of the presence of tumor without a biopsy. After exhibiting usefulness of MPM imaging for bladder cancer, we will look at other organs beginning with the colon.

Condition Intervention Phase
Bladder Cancer
Prostate Cancer
Other: Multiphoton microscopy
Phase 1

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Use of Multiphoton Microscopy in the Diagnosis of Cancer

Resource links provided by NLM:

Further study details as provided by Weill Medical College of Cornell University:

Primary Outcome Measures:
  • After several delays, the multiphoton microscope has been delivered to Weill Cornell Medical College. We have been using this time to set-up and fine tune the multiphoton microscope. As of current, no negative events have occurred. [ Time Frame: 10/14/2007 to 2/15/2008 ]

Enrollment: 344
Study Start Date: June 2005
Study Completion Date: September 2015
Primary Completion Date: September 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: MPM
Subject tissue was reviewed using multiphoton microscopy
Other: Multiphoton microscopy
Use of multiphoton microscopy to diagnose cancer

Detailed Description:
Same as above

Ages Eligible for Study:   21 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Anyone who presents with bladder and/or prostate cancer
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Please refer to this study by its identifier: NCT00652210

United States, New York
Weill Cornell Medical College
New York, New York, United States, 10065
Sponsors and Collaborators
Weill Medical College of Cornell University
Principal Investigator: Douglas S Scherr, M.D. Weill Medical College of Cornell University
  More Information

Responsible Party: Douglas S. Scherr, Associate Professor, Weill Medical College of Cornell University Identifier: NCT00652210     History of Changes
Other Study ID Numbers: 0506007919
Study First Received: March 31, 2008
Last Updated: December 8, 2015

Keywords provided by Weill Medical College of Cornell University:
Bladder cancer
prostate cancer
multiphoton microscopy

Additional relevant MeSH terms:
Prostatic Neoplasms
Urinary Bladder Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases
Urologic Neoplasms
Urinary Bladder Diseases
Urologic Diseases processed this record on April 28, 2017