Pre-shock Cardiopulmonary Resuscitation to Patients With Out-of-hospital Resuscitation, A Randomised Clinical Trial (CPR)
|ClinicalTrials.gov Identifier: NCT00650962|
Recruitment Status : Completed
First Posted : April 2, 2008
Last Update Posted : January 5, 2012
- Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe (L.Wik,2002). However, it's effectiveness in the Asian countries, where most firstly recorded rhythm in out-of-hospital cardiac arrests patients were asystole/pulseless electric activity rather than ventricular fibrillation / ventricular tachycardia, were not explored yet.
- This trial was designed to exam if pre-shock cardiopulmonary resuscitation by emergency medical technicians improves the outcome of all out-of-hospital cardiac arrest patients in an Asian metropolitan city.
|Condition or disease||Intervention/treatment|
|Cardiac Arrest||Other: cardiopulmonary resuscitation Other: Rhythm analysis|
- Different from data from the Western countries, non-shockable rhythm (Asystole/pulseless electric activity) was responsible for most out-of-hospital cardiac arrest patients(80%~90%) in metropolitan Taipei.
- Response time in Taipei emergency medical service was longer than 5 minutes.
- Bystander cardiopulmonary resuscitation rate were relatively low in Taipei.
- Cardiopulmonary resuscitation is the only known method to save out-of-hospital cardiac arrest patients with asystole/pulseless electric activity. For those suffered from ventricular fibrillation/ ventricular tachycardia,previous studies revealed pre-shock cardiopulmonary resuscitation may have the potential to improve the outcome.
- Study hypothesis: Compared with current standard resuscitative sequence (basic life support protocol in Guideline 2005), longer pre-shock cardiopulmonary resuscitation provided to all out-of-hospital cardiac arrest patients in Taipei may improve the outcome of them.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||1666 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Does Longer Pre-shock Cardiopulmonary Resuscitation Improve the Outcome of Patients With Out-of-hospital Cardiac Arrest? A Randomized Control Trial.|
|Study Start Date :||February 2008|
|Primary Completion Date :||December 2009|
|Study Completion Date :||December 2009|
Active Comparator: CPR first
Compression First (CF)
Other: cardiopulmonary resuscitation
10 cycles of 30:2 cardiopulmonary resuscitation before rhythm analysis by AED
Other Name: automatic external defibrillator
Active Comparator: Analysis First
Rhythm analysis first
Other: Rhythm analysis
Rhythm analysis as soon as AED is ready
- Sustained ROSC >= 2 hours [ Time Frame: 180 days ]
- surival to ICU admission [ Time Frame: 180 days ]
- survival to hospital discharge [ Time Frame: 180 days ]
- Rates of good neurology recovery (CPC 1 &2) [ Time Frame: 180 days ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00650962
|Department of Emergency Medicine, National Taiwan University Hospital|
|Principal Investigator:||Matthew Huei-Ming Ma, MD, PHD||Department of Emergency Medicine, NTUH.|