Pre-shock Cardiopulmonary Resuscitation to Patients With Out-of-hospital Resuscitation, A Randomised Clinical Trial (CPR)
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|ClinicalTrials.gov Identifier: NCT00650962|
Recruitment Status : Completed
First Posted : April 2, 2008
Last Update Posted : January 5, 2012
- Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe (L.Wik,2002). However, it's effectiveness in the Asian countries, where most firstly recorded rhythm in out-of-hospital cardiac arrests patients were asystole/pulseless electric activity rather than ventricular fibrillation / ventricular tachycardia, were not explored yet.
- This trial was designed to exam if pre-shock cardiopulmonary resuscitation by emergency medical technicians improves the outcome of all out-of-hospital cardiac arrest patients in an Asian metropolitan city.
|Condition or disease||Intervention/treatment||Phase|
|Cardiac Arrest||Other: cardiopulmonary resuscitation Other: Rhythm analysis||Not Applicable|
- Different from data from the Western countries, non-shockable rhythm (Asystole/pulseless electric activity) was responsible for most out-of-hospital cardiac arrest patients(80%~90%) in metropolitan Taipei.
- Response time in Taipei emergency medical service was longer than 5 minutes.
- Bystander cardiopulmonary resuscitation rate were relatively low in Taipei.
- Cardiopulmonary resuscitation is the only known method to save out-of-hospital cardiac arrest patients with asystole/pulseless electric activity. For those suffered from ventricular fibrillation/ ventricular tachycardia,previous studies revealed pre-shock cardiopulmonary resuscitation may have the potential to improve the outcome.
- Study hypothesis: Compared with current standard resuscitative sequence (basic life support protocol in Guideline 2005), longer pre-shock cardiopulmonary resuscitation provided to all out-of-hospital cardiac arrest patients in Taipei may improve the outcome of them.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||1666 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Does Longer Pre-shock Cardiopulmonary Resuscitation Improve the Outcome of Patients With Out-of-hospital Cardiac Arrest? A Randomized Control Trial.|
|Study Start Date :||February 2008|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||December 2009|
Active Comparator: CPR first
Compression First (CF)
Other: cardiopulmonary resuscitation
10 cycles of 30:2 cardiopulmonary resuscitation before rhythm analysis by AED
Other Name: automatic external defibrillator
Active Comparator: Analysis First
Rhythm analysis first
Other: Rhythm analysis
Rhythm analysis as soon as AED is ready
- Sustained ROSC >= 2 hours [ Time Frame: 180 days ]
- surival to ICU admission [ Time Frame: 180 days ]
- survival to hospital discharge [ Time Frame: 180 days ]
- Rates of good neurology recovery (CPC 1 &2) [ Time Frame: 180 days ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00650962
|Department of Emergency Medicine, National Taiwan University Hospital|
|Principal Investigator:||Matthew Huei-Ming Ma, MD, PHD||Department of Emergency Medicine, NTUH.|