Vitamin D Binding Protein (Gc) Allele Variation Effects Response to Vitamin D Treatment (Gc)
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|ClinicalTrials.gov Identifier: NCT00650780|
Recruitment Status : Completed
First Posted : April 2, 2008
Last Update Posted : April 2, 2008
|Condition or disease|
|Vitamin D Status|
We suspect that the wide range of response is effected by other factors such as variation in Vitamin D binding protein (the major transporter of Vitamin D metabolites).
Gc, also known as Vitamin D binding protein (DBP), group specific component, or Gc globulin, is a 52-58 kDa multifunctional plasma protein, synthesized in the liver. The gene encoding for Gc is located on chromosome 4, and three common co-dominant alleles give rise to three phenotypes (Gc1s, Gc1f, and Gc2). Gc binds actin, recruits neutrophil leukocytes and converts into a macrophage- and osteoclast- activating factor. It also is the major transporter of Vitamin D and its' metabolites. Lauridsen et al. showed that Gc phenotype correlates with 25(OH)D levels in a group of postmenopausal women.
This study proposes that Gc phenotype accounts for some of the variation in response of 25(OH)D levels after treatment with oral Vitamin D.
|Study Type :||Observational|
|Actual Enrollment :||29 participants|
|Official Title:||Vitamin D Binding Protein (Gc) Allele Variation Effects Response to Vitamin D Treatment|
|Study Start Date :||October 2007|
|Primary Completion Date :||January 2008|
|Study Completion Date :||January 2008|
All of the subjects will have measurements of Gc concentration and phenotype
- Gc concentration and phenotype [ Time Frame: at 1st visit ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00650780
|United States, Nebraska|
|Omaha, Nebraska, United States, 68131|
|Principal Investigator:||Laura Armas, MD||Creighton University|