Effects of Whole-Body Vibration Exercise on Serum IGF-1 in Fibromyalgia

This study has been completed.

Sponsor:

ClinicalTrials.gov Identifier:

NCT00650715

First Posted: April 2, 2008

Last Update Posted: April 2, 2008

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

Information provided by:

Institut Nacional d'Educacio Fisica de Catalunya

Purpose

The purpose of this study was to investigate the acute and chronic effect of whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia (FM). It was hypothesized that women with FM would exhibit an increase in IGF-1 following both acute and chronic WBV. Twenty-four women with FM were randomized into two groups: Vibration Group (VG) and Control Group (CG). The VG underwent a protocol with WBV exercise twice a week for a total of six weeks, whereas the CG performed the same protocol without vibratory stimulus. Both groups continued with their usual pharmacological treatment. Serum IGF-1 levels were determined using Enzyme-Linked Immunosorbent Assay (ELISA). To test the effect of chronic WBV, serum IGF-1 measurements were taken at baseline and at weeks 1,3, and 6 of intervention. To test the effect of acute WBV, within week 1, serum IGF-1 measurements were taken before and immediately following a session of WBV.

Condition	Intervention
Fibromyalgia Hormonal Responses to Exercise in Patients With Fibromyalgia.	Device: Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands Device: Placebo Whole-body vibration exercise


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment
Official Title:	Effect of Acute and Chronic Whole-Body Vibration Exercise on Serum Insulin-Like Growth Factor-1 Levels in Women With Fibromyalgia

Resource links provided by NLM:

MedlinePlus related topics: Exercise and Physical Fitness Fibromyalgia

U.S. FDA Resources

Further study details as provided by Institut Nacional d'Educacio Fisica de Catalunya:

Primary Outcome Measures:

Serum IGF-1 levels [ Time Frame: Baseline, Week 1, Week 3, Week 6 ]


Enrollment:	24
Study Start Date:	December 2004
Study Completion Date:	January 2005
Primary Completion Date:	January 2005 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Active Comparator: VG Vibration Group (VG) underwent a protocol with whole-body vibration exercise twice a week for a total of six weeks. The group continued with their usual pharmacological treatment.	Device: Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands Six exercises (static and dynamic tasks) while standing on a Whole-body vibration platform. The six exercises (30 seconds each) were repeated six times with a recovery of 3 minutes in between. The Whole-body vibration intensity was kept constant at 30 Hz of frequency and 2 mm of amplitude.
Placebo Comparator: CG The Control Group (CG) underwent the same protocol of exercises than VG but without vibratory stimulus. The CG continued with their usual pharmacological treatment.	Device: Placebo Whole-body vibration exercise Six exercises (static and dynamic tasks) while standing on a Whole-body vibration platform. The six exercises (30 seconds each) were repeated six times with a recovery of 3 minutes in between. All exercises were performed without the influence of a vibratory stimulus.

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:	35 Years to 69 Years (Adult, Senior)
Sexes Eligible for Study:	Female
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients diagnosed of fibromyalgia according to the American College of Rheumatology criteria for at least three years.

Exclusion Criteria:

Orthopedic limitation, or cardiovascular, pulmonary, or metabolic disease that would preclude exercise.
Participation in any other study.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00650715

Locations


Spain
Institut Nacional d'Educación Física de Catalunya
Barcelona, Spain, 08038

Sponsors and Collaborators

Institut Nacional d'Educacio Fisica de Catalunya

Investigators


Principal Investigator:	Eduard Alentorn-Geli, MD	INEFC

More Information


Responsible Party:	Eduard Alentorn-Geli, MD, INEFC
ClinicalTrials.gov Identifier:	NCT00650715 History of Changes
Other Study ID Numbers:	WBVIGF1FM
First Submitted:	March 31, 2008
First Posted:	April 2, 2008
Last Update Posted:	April 2, 2008
Last Verified:	March 2008

Keywords provided by Institut Nacional d'Educacio Fisica de Catalunya:


Fibromyalgia Whole-Body vibration Exercise IGF-1

Additional relevant MeSH terms:


Fibromyalgia Myofascial Pain Syndromes Muscular Diseases Musculoskeletal Diseases	Rheumatic Diseases Neuromuscular Diseases Nervous System Diseases

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