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Trial record 2 of 3 for:    "Acromegaly" | "Hypoglycemic Agents"

Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00647179
Recruitment Status : Completed
First Posted : March 31, 2008
Last Update Posted : December 26, 2017
Aarhus University Hospital
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

Condition or disease Intervention/treatment
Acromegaly Excessive Growth Hormone Secretion Insulin Resistance Procedure: Transsphenoidal adenomectomy

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Study Type : Observational
Actual Enrollment : 27 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
Study Start Date : February 2008
Actual Primary Completion Date : December 7, 2016
Actual Study Completion Date : December 7, 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy
Drug Information available for: Insulin

Group/Cohort Intervention/treatment
Patients recently diagnosed with acromegaly
Procedure: Transsphenoidal adenomectomy

Primary Outcome Measures :
  1. Insulin sensitivity [ Time Frame: Before and after treatment ]

Secondary Outcome Measures :
  1. QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance [ Time Frame: Before and after treatment ]

Biospecimen Retention:   Samples Without DNA
Whole blood, serum, muscle samples, fat samples

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patiens recently diagnoses with acromegaly, recruited from the clinic

Inclusion Criteria:

  • Written consent
  • Age between 18 and 70
  • Recently diagnosed with acromegaly

Exclusion Criteria:

  • NYHA 3
  • Uncontrolled hypertension
  • Known cerebrovascular disease
  • Proliferative retinopatia

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00647179

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Department of Endocrinology, Aarhus University Hospital
Aarhus C, Aarhus, Denmark, DK-8000
Sponsors and Collaborators
University of Aarhus
Aarhus University Hospital
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Principal Investigator: Jens Otto L. Jørgensen, Professor MD Aarhus University Hospital, Department of Endocrinology

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Responsible Party: University of Aarhus Identifier: NCT00647179     History of Changes
Other Study ID Numbers: MM-ISA-20070130
First Posted: March 31, 2008    Key Record Dates
Last Update Posted: December 26, 2017
Last Verified: December 2017

Keywords provided by University of Aarhus:
Growth Hormone
Insulin resistance
Glucose tolerance
Body Composition
Substrate metabolism

Additional relevant MeSH terms:
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Hypoglycemic Agents
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Bone Diseases, Endocrine
Bone Diseases
Musculoskeletal Diseases
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Endocrine System Diseases
Physiological Effects of Drugs