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Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

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ClinicalTrials.gov Identifier: NCT00647179
Recruitment Status : Completed
First Posted : March 31, 2008
Last Update Posted : December 25, 2017
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

Condition or disease Intervention/treatment
Acromegaly Excessive Growth Hormone Secretion Insulin Resistance Procedure: Transsphenoidal adenomectomy

Study Design

Study Type : Observational
Actual Enrollment : 27 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
Study Start Date : February 2008
Primary Completion Date : December 7, 2016
Study Completion Date : December 7, 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy
Drug Information available for: Insulin
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
1
Patients recently diagnosed with acromegaly
Procedure: Transsphenoidal adenomectomy
Surgery


Outcome Measures

Primary Outcome Measures :
  1. Insulin sensitivity [ Time Frame: Before and after treatment ]

Secondary Outcome Measures :
  1. QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance [ Time Frame: Before and after treatment ]

Biospecimen Retention:   Samples Without DNA
Whole blood, serum, muscle samples, fat samples

Eligibility Criteria

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patiens recently diagnoses with acromegaly, recruited from the clinic
Criteria

Inclusion Criteria:

  • Written consent
  • Age between 18 and 70
  • Recently diagnosed with acromegaly

Exclusion Criteria:

  • NYHA 3
  • Uncontrolled hypertension
  • Known cerebrovascular disease
  • Proliferative retinopatia
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00647179


Locations
Denmark
Department of Endocrinology, Aarhus University Hospital
Aarhus C, Aarhus, Denmark, DK-8000
Sponsors and Collaborators
University of Aarhus
Aarhus University Hospital
Investigators
Principal Investigator: Jens Otto L. Jørgensen, Professor MD Aarhus University Hospital, Department of Endocrinology
More Information

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00647179     History of Changes
Other Study ID Numbers: MM-ISA-20070130
M-20070130
First Posted: March 31, 2008    Key Record Dates
Last Update Posted: December 25, 2017
Last Verified: December 2017

Keywords provided by University of Aarhus:
Acromegaly
Growth Hormone
Insulin resistance
Glucose tolerance
Body Composition
Substrate metabolism

Additional relevant MeSH terms:
Insulin Resistance
Acromegaly
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Bone Diseases, Endocrine
Bone Diseases
Musculoskeletal Diseases
Hyperpituitarism
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Endocrine System Diseases
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs