Impact of Left Atrial Function on Postoperative Atrial Fibrillation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00646997
Recruitment Status : Completed
First Posted : March 31, 2008
Last Update Posted : June 30, 2008
Information provided by:
Florence Nightingale Hospital, Istanbul

Brief Summary:
We aimed to demonstrate the impact of left atrial functions which were evaluated by three different echocardiographic modalities , on postoperative atrial fibrillation.

Condition or disease
Atrial Fibrillation

Detailed Description:
Postoperative atrial fibrillation after coronary artery bypass greft operation (CABG) is major complication with a prevalence of 10-50%. Although the men mechanism is not known, in recent studies, age and left atrial function have been demonstrated as the most responsible factors. Velocity vector imaging (VVI) is a new modality which may give accurate and detailed information on both left atrial segmental and global function. In this study, our aim was to assess preoperative left atrial function by using three different echocardiographic modalities, VVI, tissue Doppler imaging and conventional echocardiography and evaluate the relation between the left atrial functions and the development of post-operative atrial fibrillation after CABG.

Study Type : Observational
Estimated Enrollment : 80 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Impact Of Velocity Vector Imaging, Tissue Doppler Imaging, Conventional Echocardiography And P Wave Dispertion In Evaluating Post-Operative Atrial Fibrillation After Coronary Bypass Graft Surgery
Study Start Date : March 2008
Actual Primary Completion Date : May 2008
Actual Study Completion Date : May 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Patients with postoperative atrial fibrillation
Patients without postoperative atrial fibrillation.

Primary Outcome Measures :
  1. Velocity vector imaging derived left atrial segmenter function, Tissue doppler derved left atrial segmenter function, conventional analysis of atrial function by 2D and pulsed wave echocardiography. [ Time Frame: April 2008 ]

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Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Tertiary care clinic

Inclusion Criteria:

  • 1Coronary artery disease evidenced by coronary angiography
  • 2Patients with a decision of undergoing elective coronary artery bypass greft operation
  • 3Sinus rhythm in electrocardiography

Exclusion Criteria:

  • 1Rheumatic valve disease
  • 2Having prosthetic valve
  • 3CABG accompanied by other cardiac interventions (such as valvular surgery, ASD closure...etc)
  • 4Left ventricular l ejection fraction <40%
  • 5Mild to moderate mitral stenosis or regurgitation
  • 6Having atrial fibrillation or a history of atrial fibrillation attach during the last two weeks.
  • 7Congenital heart disease
  • 8Chronic liver disease
  • 9Chronic renal disease
  • 10Malignancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00646997

TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology
Istanbul, Turkey, 34381
Sponsors and Collaborators
Florence Nightingale Hospital, Istanbul
Study Director: Saide Aytekin, Professor T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology

Responsible Party: Prof.Dr.Saide Aytekin, T.C. Istanbul Bilim University, Florence Nightingale Hospital Identifier: NCT00646997     History of Changes
Other Study ID Numbers: YT1977/2
First Posted: March 31, 2008    Key Record Dates
Last Update Posted: June 30, 2008
Last Verified: June 2008

Keywords provided by Florence Nightingale Hospital, Istanbul:
atrial fibrillation, left atrium, velocity vector imaging

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes