Non-Invasive Positive Pressure Ventilation and Adult Respiratory Distress Syndrome (ARDS) (NPPV)
|ClinicalTrials.gov Identifier: NCT00644930|
Recruitment Status : Completed
First Posted : March 27, 2008
Last Update Posted : March 27, 2008
|Condition or disease||Intervention/treatment||Phase|
|Acute Respiratory Distress Syndrome||Device: the application of NPPV Device: invasive ventilation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Efficacy of Non-Invasive Positive Pressure Ventilation in ARDS: A Controlled Cohort Study|
|Study Start Date :||August 2003|
|Actual Primary Completion Date :||September 2005|
|Actual Study Completion Date :||December 2007|
ARDS patients in the NPPV group showing no indications for urgent intubation received NPPV in addition to standard medical therapy, and those with indications were intubated.
Device: the application of NPPV
ARDS patients in the NPPV group showing no indications for urgent intubation received NPPV in addition to standard medical therapy, and those with indications were intubated. BIPAP Vision machine (Respironics, PA, USA) were used for NPPV.
Other Name: NPPV group
Active Comparator: 2
Patients in the standard therapy group without indications for urgent intubation were only given standard medical therapy (such as oxygen, antibiotics, and bronchodilators), and IMV through an endotracheal tube was applied when intubation criteria were met.
Device: invasive ventilation
Standard therapy group (invasive ventilation). Patients in need of endotracheal intubation were mechanically ventilated with Amadeus (Hamilton, Via Nova, Switzerland) and Esprit (Respironics, PA, USA) ventilators in the assist—control or synchronized intermittent mandatory ventilation (SIMV) mode.
Other Name: Standard therapy group
- Intubation rate [ Time Frame: 48 hours ]
- Hospital mortality
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00644930
|Eskisehir Osmangazi University, Medical Faculty,|
|Eskisehir, Merkez, Turkey, 26040|
|Study Chair:||Irfan Ucgun, Ass Prof Dr||Eskisehir Osmangazi University, Medical Faculty, Department of Chest Dis.|