The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization
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This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.
Condition or disease
Coronary Artery DiseaseChest Pain
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.
The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty [ Time Frame: 24 hours after the administration of clopidotrel ]
The percentage of platelets that are collagen coated after the administration of clopidogrel.
Secondary Outcome Measures :
The Percentage of Coated Platelets After Coronary Angiography and/or PCI [ Time Frame: 6 hrs after procedure ]
The percentage of coated platelets 24 hours after coronary angiography and/or PCI
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention