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The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00644657
First Posted: March 27, 2008
Last Update Posted: October 7, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Oklahoma
  Purpose
This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.

Condition Intervention
Coronary Artery Disease Chest Pain Drug: Clopidogrel

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

Resource links provided by NLM:


Further study details as provided by University of Oklahoma:

Primary Outcome Measures:
  • The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty [ Time Frame: 24 hours after the administration of clopidotrel ]
    The percentage of platelets that are collagen coated after the administration of clopidogrel.


Secondary Outcome Measures:
  • The Percentage of Coated Platelets After Coronary Angiography and/or PCI [ Time Frame: 6 hrs after procedure ]
    The percentage of coated platelets 24 hours after coronary angiography and/or PCI


Enrollment: 27
Study Start Date: March 2007
Study Completion Date: September 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Clopidogrel
    All subjects will receive a 300 mg loading dose
    Other Name: Plavix
Detailed Description:
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention

Exclusion Criteria:

  • Acute coronary syndrome
  • Unable to tolerate clopidogrel
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00644657


Locations
United States, Oklahoma
VA Medical Center, 1F187
Oklahoma City, Oklahoma, United States, 73104-5076
Sponsors and Collaborators
University of Oklahoma
Investigators
Principal Investigator: Eliot Schechter, MD University of Oklahoma
  More Information

Responsible Party: University of Oklahoma
ClinicalTrials.gov Identifier: NCT00644657     History of Changes
Other Study ID Numbers: 13291
First Submitted: March 24, 2008
First Posted: March 27, 2008
Results First Submitted: January 6, 2011
Results First Posted: October 7, 2011
Last Update Posted: October 7, 2011
Last Verified: September 2011

Keywords provided by University of Oklahoma:
Platelets, platelet aggregation inhibitors

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Chest Pain
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Clopidogrel
Ticlopidine
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Purinergic P2 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Fibrinolytic Agents
Fibrin Modulating Agents
Cytochrome P-450 CYP2C19 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors