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Does Low-Dose Aspirin Improve Outcome in In Vitro Fertilisation/Intra Cytoplasmatic Sperm Injection (IVF/ICSI)?

This study has been completed.
Information provided by:
University Hospital, Ghent Identifier:
First received: March 20, 2008
Last updated: March 26, 2008
Last verified: March 2008
To investigate the effect of daily administration of low-dose aspirin, compared to placebo, on IVF and ICSI outcome.

Condition Intervention Phase
Infertility Drug: aspirin Drug: placebo Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Does Low-Dose Aspirin Improve Outcome in IVF/ICSI? A Prospective, Randomized, Double Blind Placebo Controlled Trial

Resource links provided by NLM:

Further study details as provided by University Hospital, Ghent:

Primary Outcome Measures:
  • Number of oocytes retrieved
  • Clinical pregnancy rate per embryo transfer

Secondary Outcome Measures:
  • Live birth rate per cycle

Enrollment: 201
Study Start Date: April 2000
Study Completion Date: December 2007
Arms Assigned Interventions
Experimental: 1
oral administration of aspirin 100 mg
Drug: aspirin
oral administration of aspirin 100 mg
Placebo Comparator: 2
oral administration of placebo
Drug: placebo
oral administration of placebo


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Dutch-speaking women
  • Starting a first or second IVF/ICSI cycle

Exclusion Criteria:

  • Women suffering from

    • platelet dysfunction
    • thrombopenia
    • gastro-intestinal ulcers
    • recurrent gastritis
    • aspirin hypersensitivity
  • Women on treatment with anticoagulants or aspirin
  Contacts and Locations
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Please refer to this study by its identifier: NCT00644085

University Hospital Ghent
Ghent, Belgium, 9000
Sponsors and Collaborators
University Hospital, Ghent
Principal Investigator: Marc Dhont, MD, PhD University Hospital, Ghent
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Kaatje Dirckx, MD, University Hospital Ghent Identifier: NCT00644085     History of Changes
Other Study ID Numbers: 99/191
Study First Received: March 20, 2008
Last Updated: March 26, 2008

Keywords provided by University Hospital, Ghent:

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Antipyretics processed this record on September 19, 2017