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Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00643266
Recruitment Status : Completed
First Posted : March 26, 2008
Last Update Posted : November 16, 2018
Information provided by (Responsible Party):
Dr. Nicole D. Anderson, Baycrest

Brief Summary:

We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.

Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.

Condition or disease Intervention/treatment Phase
Amnestic Mild Cognitive Impairment Aging Behavioral: Recollection Training Behavioral: Control Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 91 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Memory Interventions for Older Adults
Study Start Date : February 2008
Actual Primary Completion Date : August 2013
Actual Study Completion Date : August 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory

Arm Intervention/treatment
Experimental: 1
Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days
Behavioral: Recollection Training
Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.
Other Name: Memory training

Active Comparator: 2
Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants
Behavioral: Control
Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain
Other Name: Educational Control

Primary Outcome Measures :
  1. Recollection estimates [ Time Frame: Immediately post-training and three months post-training ]
    Recollection, defined as Correct "yes" responses to "Same" repetitions minus Incorrect "yes" responses to "Different" repetitions, as a function of condition (trained versus control), lag (3, 16) and time (pre-, post-, and 3 month follow-up)

Secondary Outcome Measures :
  1. Brain activation as assessed by functional magnetic resonance imaging [ Time Frame: Immediately post-training ]
    Prefrontal (inferior, middle, and superior frontal gyri) activation for Different Repetitions minus Same Repetitions, as a function of group (trained versus control), lag (3, 16), and time (pre, post). Additional analyses will compare trained versus control older adults with younger adults on these measures at baseline (pre). Analyses will include an exploration of prefrontal laterality of the effects (left minus right), to see whether training induces greater bilaterality of activation.

  2. Transfer to other recollection-dependent task and to subjective memory measures [ Time Frame: Immediately post-training and three months post-training ]
    Source memory, self-ordered pointing, n-back, a Sternberg task, CVLT, an AB-AC test of proactive interference, the Memory Controllability Inventory, Multifactorial Memory Questionnaire (Ability and Contentment subscales), Meta-Memory in Adulthood questionnaire (locus of control, anxiety, and capability subscales), and an in-house measure of the efficacy of the control program

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 90 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 65-90 years old
  • English as a first language or learned before kindergarten
  • Right handed

Exclusion Criteria:

  • Neurologic disorder
  • Major medical disorder affecting cognition
  • Psychiatric disorder
  • Metal in the body that poses a hazard in the MRI scanner

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00643266

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Canada, Ontario
Toronto, Ontario, Canada, M6A 2E1
Sponsors and Collaborators
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Principal Investigator: Nicole D Anderson, PhD, CPsych Baycrest

Publications of Results:
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Responsible Party: Dr. Nicole D. Anderson, Senior Scientist, Baycrest Identifier: NCT00643266    
Other Study ID Numbers: RecollectionTraining
CIHR MOP 67015
ASC 08 95
First Posted: March 26, 2008    Key Record Dates
Last Update Posted: November 16, 2018
Last Verified: November 2018
Keywords provided by Dr. Nicole D. Anderson, Baycrest:
recollection training
amnestic mild cognitive impairment
Additional relevant MeSH terms:
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Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders