Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

This study has been completed.
Information provided by:
Baqiyatallah Medical Sciences University
ClinicalTrials.gov Identifier:
First received: March 19, 2008
Last updated: March 24, 2008
Last verified: March 2008
to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

Condition Intervention Phase
Chronic Bronchitis
Drug: helium:oxygen mixture
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Resource links provided by NLM:

Further study details as provided by Baqiyatallah Medical Sciences University:

Estimated Enrollment: 23
Study Start Date: April 2007
Arms Assigned Interventions
Experimental: 1 Drug: helium:oxygen mixture


Ages Eligible for Study:   38 Years to 59 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • exposure to sulfur mustard
  • worsening dyspnea during the last 10 days
  • respiratory rate of >25/min
  • arterial pH<7.35
  • PaCO2 of >50 mmHg
  • PaO2 of <50 mmHg

Exclusion Criteria:

  • recent pneumothorax (<1 month)
  • severe respiratory failure or hemodynamic instability with forthcoming intubation
  • FIO2 of <0.4
  • impaired consciousness or absence of patient cooperation
  • facial lesions precluding NIPPV
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00642447

Iran, Islamic Republic of
Tehran, Iran, Islamic Republic of, 19945-546
Sponsors and Collaborators
Baqiyatallah Medical Sciences University
  More Information

ClinicalTrials.gov Identifier: NCT00642447     History of Changes
Other Study ID Numbers: B12406 
Study First Received: March 19, 2008
Last Updated: March 24, 2008
Health Authority: Iran: Baqiyatallah Medical Sciences University

Keywords provided by Baqiyatallah Medical Sciences University:
noninvasive ventilation
sulfur mustard
chronic bronchitis

Additional relevant MeSH terms:
Mustard Gas
Bronchitis, Chronic
Bronchial Diseases
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases
Respiratory Tract Infections
Dermatologic Agents
Pharmacologic Actions
Therapeutic Uses

ClinicalTrials.gov processed this record on April 27, 2016