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The Effect of Nocturnal Haemodialysis on Arterial Stiffness

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00641875
First Posted: March 24, 2008
Last Update Posted: April 27, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Melbourne Health
  Purpose
Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Condition Intervention
End Stage Renal Disease Arterial Stiffness Procedure: Nocturnal Hemodialysis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Resource links provided by NLM:


Further study details as provided by Melbourne Health:

Primary Outcome Measures:
  • To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis. [ Time Frame: 12 months ]

Secondary Outcome Measures:
  • To examine the relationship between arterial stiffness and clinical and biochemical parameters [ Time Frame: 12 months ]

Enrollment: 30
Study Start Date: December 2005
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All participants are adult patients who are receiving maintenance dialysis at the North West Dialysis Service. Consecutive patients enrolled in the Nocturnal Haemodialysis program are invited to participate in the study
Criteria

Inclusion Criteria:

  • adult dialysis patients
  • able to perform home nocturnal haemodialysis

Exclusion Criteria:

  • age < 18 and > 80 years
  • any patient who is anticipating a live renal transplantation in forthcoming 12 months
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00641875


Sponsors and Collaborators
Melbourne Health
Investigators
Principal Investigator: Michael Lian, FRACP, MBBS Department of Nephrology, Melbourne Health
  More Information

Responsible Party: Melbourne Health
ClinicalTrials.gov Identifier: NCT00641875     History of Changes
Other Study ID Numbers: 2004.050
First Submitted: March 17, 2008
First Posted: March 24, 2008
Last Update Posted: April 27, 2015
Last Verified: April 2015

Keywords provided by Melbourne Health:
arterial stiffness
artery
aortic pulse wave velocity
pulse wave analysis
augmentation index
end stage renal disease
nocturnal hemodialysis
extended hours of hemodialysis
cardiovascular
hemodialysis

Additional relevant MeSH terms:
Kidney Diseases
Kidney Failure, Chronic
Urologic Diseases
Renal Insufficiency, Chronic
Renal Insufficiency