The Effect of Nocturnal Haemodialysis on Arterial Stiffness

This study has been completed.
Information provided by (Responsible Party):
Melbourne Health Identifier:
First received: March 17, 2008
Last updated: April 23, 2015
Last verified: April 2015
Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Condition Intervention
End Stage Renal Disease
Arterial Stiffness
Procedure: Nocturnal Hemodialysis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Resource links provided by NLM:

Further study details as provided by Melbourne Health:

Primary Outcome Measures:
  • To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis. [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • To examine the relationship between arterial stiffness and clinical and biochemical parameters [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Enrollment: 30
Study Start Date: December 2005
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All participants are adult patients who are receiving maintenance dialysis at the North West Dialysis Service. Consecutive patients enrolled in the Nocturnal Haemodialysis program are invited to participate in the study

Inclusion Criteria:

  • adult dialysis patients
  • able to perform home nocturnal haemodialysis

Exclusion Criteria:

  • age < 18 and > 80 years
  • any patient who is anticipating a live renal transplantation in forthcoming 12 months
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00641875

Sponsors and Collaborators
Melbourne Health
Principal Investigator: Michael Lian, FRACP, MBBS Department of Nephrology, Melbourne Health
  More Information

No publications provided

Responsible Party: Melbourne Health Identifier: NCT00641875     History of Changes
Other Study ID Numbers: 2004.050 
Study First Received: March 17, 2008
Last Updated: April 23, 2015
Health Authority: Australia: Human Research Ethics Committee

Keywords provided by Melbourne Health:
arterial stiffness
aortic pulse wave velocity
pulse wave analysis
augmentation index
end stage renal disease
nocturnal hemodialysis
extended hours of hemodialysis

Additional relevant MeSH terms:
Kidney Diseases
Kidney Failure, Chronic
Renal Insufficiency
Renal Insufficiency, Chronic
Urologic Diseases processed this record on February 11, 2016