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Acamprosate for Treatment of Compulsive Behaviors and Craving in Parkinson's Disease

This study has been withdrawn prior to enrollment.
(PI left site)
National Parkinson Foundation
Information provided by (Responsible Party):
Joohi Jimenez-Shahed, Baylor College of Medicine Identifier:
First received: December 28, 2007
Last updated: November 10, 2015
Last verified: November 2015
The purpose of this study is to determine how many patients with Parkinson's disease have compulsive behaviors, and what types of behaviors they have. This study will also determine if acamprosate can be used to treat compulsive behaviors in Parkinson's disease patients.

Condition Intervention
Parkinson's Disease
Drug: acamprosate

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Acamprosate for Treatment of Compulsive Behaviors and Craving in Parkinson's Disease

Resource links provided by NLM:

Further study details as provided by Joohi Jimenez-Shahed, Baylor College of Medicine:

Primary Outcome Measures:
  • safety and efficacy compared to baseline scores [ Time Frame: 6 months ]

Secondary Outcome Measures:
  • change from baseline assessment tools used in the study [ Time Frame: 6 months ]

Enrollment: 0
Study Start Date: August 2006
Study Completion Date: September 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: acamprosate
    333 mg 2 tabs tid

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. Idiopathic Parkinson's disease
  2. Active dopaminergic therapy at stable dose for one month (levodopa or dopamine agonist)
  3. Able and willing to complete Rating Scales
  4. Presence of one or more compulsive behavior based on responses to Rating Scales (defined as >5 on the SOGS; >17 on the YBOCS-SV and YBOCS-CUV; >1.7 on the SCS for women and >2.1 on the SCS for men; >15 on the YBOCS-BE, >5.5 on the CQ).
  5. Written informed consent

Inclusion criteria (controls):

  1. No significant psychiatric disease
  2. Able and willing to complete Rating Scales
  3. Written informed consent

Exclusion Criteria:

  1. No anticipated need for adjustment of medications for Parkinson's disease
  2. Current participation in another clinical study
  3. History of unstable psychiatric disease (as determined by the Principal Investigator)
  4. Women of childbearing age not using appropriate contraceptive methods (oral contraceptives, condoms, surgery)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00640952

United States, Texas
PDCMDC 6550 Fannin, Suite 1801
Houston, Texas, United States, 77030
Sponsors and Collaborators
Baylor College of Medicine
National Parkinson Foundation
Principal Investigator: Joohi Jimenez-Shahed, MD Baylor College of Medicine
  More Information

Additional Information:
Responsible Party: Joohi Jimenez-Shahed, Principal Investigator, Baylor College of Medicine Identifier: NCT00640952     History of Changes
Other Study ID Numbers: H-19781
Study First Received: December 28, 2007
Last Updated: November 10, 2015

Keywords provided by Joohi Jimenez-Shahed, Baylor College of Medicine:
Parkinson's disease
impulse control behaviors

Additional relevant MeSH terms:
Parkinson Disease
Compulsive Behavior
Obsessive-Compulsive Disorder
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Impulsive Behavior
Anxiety Disorders
Mental Disorders
Alcohol Deterrents processed this record on May 25, 2017