Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence
Objective: To develop a detailed treatment manual that modifies the existing CPT-C treatment protocol to allow for concurrent treatment of PTSD and AD, and to obtain some pilot data regarding its efficacy.
Hypothesis: We predict that CPT-C will significantly reduce the number of drinking days (measured by the Timeline Follow Back Method [TLFB]) and reduce the symptoms of PTSD (measured by the [CAPS and PCL] scores).
Design: This is a non-randomized, prospective study in which all participants will receive the modified CPT-C for 12 weeks by trained CPT-C clinicians, with each session lasting approximately 1-1.5 hours). Modifications to CPT-C include psychoeducation about alcohol use as an avoidance of PTSD symptoms integrated throughout treatment, integration of coping skills training for AD, weekly breathalyzer tests to measure blood alcohol level, and use and collection of daily dairies of alcohol use.
|Study Design:||Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Modification of Cognitive Processing Therapy (CPT-C) for Posttraumatic Stress Disorder (PTSD) and Alcohol Dependence (AD)|
- Alcohol use, PTSD symptoms [ Time Frame: 16 weeks ] [ Designated as safety issue: Yes ]
- quality of life [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||March 2008|
|Estimated Study Completion Date:||October 2016|
|Estimated Primary Completion Date:||October 2016 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00639288
|Contact: Mayumi Gianoli, Ph.D.||860-666-6951 ext firstname.lastname@example.org|
|Contact: Elizabeth Ralevski, Ph.D.||203-932-5711 ext email@example.com|
|United States, Connecticut|
|VA Connecticut Healthcare System - West Haven Campus||Recruiting|
|West Haven, Connecticut, United States, 06516|
|Principal Investigator:||Ismene L Petrakis, MD||Yale University|