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The Incretin Effect in Patients With Chronic Pancreatitis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00638573
Recruitment Status : Completed
First Posted : March 19, 2008
Last Update Posted : January 13, 2010
University of Copenhagen
Information provided by:
University Hospital, Gentofte, Copenhagen

Brief Summary:
The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect. In type 2 diabetes mellitus (T2DM) the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question the investigators plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus (DM) to chronic pancreatitis (CP) and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance (NGT). Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion.

Condition or disease
Chronic Pancreatitis Type 2 Diabetes Mellitus

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Study Type : Observational
Actual Enrollment : 32 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Incretin Effect in Patients With Chronic Pancreatitis With and Without Secondary Diabetes Mellitus
Study Start Date : January 2006
Study Completion Date : July 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pancreatitis

Biospecimen Retention:   Samples With DNA
Blood samples

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with chronic pancreatitis with and without secondary diabetes mellitus

Inclusion Criteria:

  • Diagnosis of chronic pancreatitis with secondary diabetes mellitus
  • Diagnosis of chronic pancreatitis with normal glucose tolerance
  • Diagnosis of type 2 diabetes
  • Normal level of hemoglobin
  • Normal level of se-creatinine

Exclusion Criteria:

  • GAD-65 autoantibodies
  • ICA autoantibodies
  • Albuminuria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00638573

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Gentofte University Hospital
Hellerup, Copenhagen County, Denmark, 2900
Sponsors and Collaborators
University Hospital, Gentofte, Copenhagen
University of Copenhagen
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Principal Investigator: Filip K Knop, MD University of Copenhagen
Study Director: Jens J Holst, MD DMSc University of Copenhagen
Study Director: Thure Krarup, MD DMSc Gentofte University Hospital

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Responsible Party: Filip K. Knop, Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen Identifier: NCT00638573     History of Changes
Other Study ID Numbers: KA04034
First Posted: March 19, 2008    Key Record Dates
Last Update Posted: January 13, 2010
Last Verified: March 2008
Additional relevant MeSH terms:
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Pancreatitis, Chronic
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pancreatic Diseases
Digestive System Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs