The Incretin Effect in Patients With Chronic Pancreatitis

This study has been completed.
University of Copenhagen
Information provided by:
University Hospital, Gentofte, Copenhagen Identifier:
First received: March 12, 2008
Last updated: January 12, 2010
Last verified: March 2008
The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect. In type 2 diabetes mellitus (T2DM) the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question the investigators plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus (DM) to chronic pancreatitis (CP) and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance (NGT). Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion.

Chronic Pancreatitis
Type 2 Diabetes Mellitus

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Incretin Effect in Patients With Chronic Pancreatitis With and Without Secondary Diabetes Mellitus

Resource links provided by NLM:

Further study details as provided by University Hospital, Gentofte, Copenhagen:

Biospecimen Retention:   Samples With DNA
Blood samples

Enrollment: 32
Study Start Date: January 2006
Estimated Study Completion Date: July 2006

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with chronic pancreatitis with and without secondary diabetes mellitus

Inclusion Criteria:

  • Diagnosis of chronic pancreatitis with secondary diabetes mellitus
  • Diagnosis of chronic pancreatitis with normal glucose tolerance
  • Diagnosis of type 2 diabetes
  • Normal level of hemoglobin
  • Normal level of se-creatinine

Exclusion Criteria:

  • GAD-65 autoantibodies
  • ICA autoantibodies
  • Albuminuria
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Please refer to this study by its identifier: NCT00638573

Gentofte University Hospital
Hellerup, Copenhagen County, Denmark, 2900
Sponsors and Collaborators
University Hospital, Gentofte, Copenhagen
University of Copenhagen
Principal Investigator: Filip K Knop, MD University of Copenhagen
Study Director: Jens J Holst, MD DMSc University of Copenhagen
Study Director: Thure Krarup, MD DMSc Gentofte University Hospital
  More Information

No publications provided

Responsible Party: Filip K. Knop, Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen Identifier: NCT00638573     History of Changes
Other Study ID Numbers: KA04034
Study First Received: March 12, 2008
Last Updated: January 12, 2010
Health Authority: Denmark: National Board of Health

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Pancreatitis, Chronic
Digestive System Diseases
Endocrine System Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Pancreatic Diseases processed this record on November 27, 2015