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Insulin Sensitivity of the Brain in Pathogenesis of Diabetes Mellitus Type 2

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2008 by University Hospital Tuebingen.
Recruitment status was:  Recruiting
German Research Foundation
Information provided by:
University Hospital Tuebingen Identifier:
First received: March 12, 2008
Last updated: March 18, 2008
Last verified: March 2008
The purpose of the study is to investigate whether insulin sensitivity of the human brain correlates with insulin sensitivity of the liver.

Condition Intervention
Human Physiology of Energy Homeostasis Drug: Human insulin Drug: Saline

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Insulin Sensitivity of the Brain in Pathogenesis of Diabetes Mellitus Typ 2

Resource links provided by NLM:

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:
  • Insulin effect on cortical function (spectral analysis) [ Time Frame: 2 weeks ]

Estimated Enrollment: 42
Study Start Date: February 2008
Estimated Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: I Drug: Human insulin
Placebo Comparator: P Drug: Saline


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age 18-70 Risk factor(s) for type 2 diabetes (e.g. overweight, family history of diabetes)

Exclusion Criteria:

  • Type 2 diabetes pregnancy acute or chronic diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00638209

Contact: Andreas Fritsche, MD +49 7071 29 80590

University Hospital Tuebingen, Internal Medicine IV Recruiting
Tuebingen, Germany, 72076
University Hospital Tuebingen Recruiting
Tuebingen, Germany, 72076
Contact: Andreas Fritsche    +49 7071 29 80590   
Sponsors and Collaborators
University Hospital Tuebingen
German Research Foundation
  More Information

Responsible Party: Prof. Andreas Fritsche, University Hospital Tuebingen, Internal Medicine IV Identifier: NCT00638209     History of Changes
Other Study ID Numbers: MEG-KFO-2
EudraCT 2006-004734-32
Study First Received: March 12, 2008
Last Updated: March 18, 2008

Additional relevant MeSH terms:
Diabetes Mellitus
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Insulin, Globin Zinc
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on September 19, 2017