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A Randomised Comparison on the Dose Requirement Between, Levobupivacaine, Ropivacaine and Bupivacaine in Intrathecal Anaesthesia

This study has been completed.
Information provided by:
Hospital Authority, Hong Kong Identifier:
First received: December 19, 2007
Last updated: October 22, 2013
Last verified: October 2013
To determine and compare the effective intrathecal dose of levobupivacaine, ropivacaine and bupivacaine for 50% of patients in lower limb surgery

Condition Intervention
Anesthesia, Conduction Surgery Procedure: Combined spinal epidural anaesthesia

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Minimum Local Anaesthetic Dose for Intrathecal Anaesthesia: a Randomised Comparison Between Levobupivacaine, Ropivacaine and Bupivacaine

Resource links provided by NLM:

Further study details as provided by Hospital Authority, Hong Kong:

Primary Outcome Measures:
  • Sensory block at 12th thoracic dermatome or above and successful conduct of the lower limb surgery up to 50 minutes after the intrathecal injection of the study drug [ Time Frame: 50 minutes after the intrathecal injection of the study drug ]

Estimated Enrollment: 75
Study Start Date: January 2006
Study Completion Date: July 2008

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • body weight=40-90kg,
  • height higher than 145cm

Exclusion Criteria:

  • Known hypersensitivity to amide local anaesthetics,
  • patients who do not understand English and Chinese,
  • Body mass index higher than 35 kg per sq metre
  Contacts and Locations
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Please refer to this study by its identifier: NCT00636974

Kwong Wah Hospital
Hong Kong, China
Sponsors and Collaborators
Hospital Authority, Hong Kong
Principal Investigator: Ying Yin Lee, Dr Department of Anaesthesiology, Kwong Wah Hospital
  More Information

Additional Information: Identifier: NCT00636974     History of Changes
Other Study ID Numbers: KW/FR/05-025
Study First Received: December 19, 2007
Last Updated: October 22, 2013

Keywords provided by Hospital Authority, Hong Kong:
Patients who are going to have regional anaesthesia for lower limbs surgery.
Leg Surgery.

Additional relevant MeSH terms:
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Local
Sensory System Agents
Peripheral Nervous System Agents processed this record on September 21, 2017