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Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

This study has been completed.
Fars Heart Foundation
Information provided by:
Shiraz University of Medical Sciences Identifier:
First received: February 14, 2008
Last updated: March 4, 2008
Last verified: March 2008
The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Condition Intervention Phase
Contrast Induced Nephropathy
Drug: sodium bicarbonate
Drug: Acetazolamide
Drug: normal salin
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Effect of Acetazolamide in Prevention of Contrast Nephropathy

Resource links provided by NLM:

Further study details as provided by Shiraz University of Medical Sciences:

Primary Outcome Measures:
  • Increased base line creatinine at least 25% [ Time Frame: 24 hr later ]

Enrollment: 240
Study Start Date: September 2007
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography
Drug: sodium bicarbonate
150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography
Other Name: no other name
Active Comparator: 2
Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography
Drug: Acetazolamide
Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography
Other Name: Diamox
Active Comparator: 3
normal salin 1cc/kg/hr before and after angiography
Drug: normal salin
1 cc/kg/hr 6 hour before and after angiography
Other Name: no other name

Detailed Description:
Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • patient that underwent coronary angiography

Exclusion Criteria:

  • serum Cr. more than 3 mg/dl
  • electrolyte and acid-base imbalance
  • pulmonary edema
  • allergy to Acetazolamide
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Please refer to this study by its identifier: NCT00634491

Iran, Islamic Republic of
Fars Heart Foundation , Kowsar hospital
Shiraz, Iran, Islamic Republic of
Sponsors and Collaborators
Shiraz University of Medical Sciences
Fars Heart Foundation
Study Chair: Maryam Pakfetrat, MD Shiraz nephro-urology research center
  More Information

Additional Information:
Responsible Party: Office of Vice Chancellor for research in Shiraz UMS, Shiraz University of Medical Science Identifier: NCT00634491     History of Changes
Other Study ID Numbers: 2438
Study First Received: February 14, 2008
Last Updated: March 4, 2008

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases
Carbonic Anhydrase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents
Physiological Effects of Drugs processed this record on April 27, 2017