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Efficacy of Vitamin C Injection on Fatigue in Workers After Work

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ClinicalTrials.gov Identifier: NCT00633581
Recruitment Status : Completed
First Posted : March 12, 2008
Last Update Posted : April 10, 2009
Information provided by:

Study Description
Brief Summary:
Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

Condition or disease Intervention/treatment Phase
Fatigue Dietary Supplement: Ascorbic acid (Vitamin C) Dietary Supplement: Normal saline Phase 2 Phase 3

Detailed Description:
Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 150 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Supportive Care
Official Title: Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial
Study Start Date : March 2008
Primary Completion Date : May 2008
Study Completion Date : May 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Fatigue Vitamin C
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: 1
Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.
Dietary Supplement: Ascorbic acid (Vitamin C)
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
Other Names:
  • Ascorbic acid
  • Merit C
Placebo Comparator: 2
Intravenous injections of 120ml of normal saline over 30 minutes.
Dietary Supplement: Normal saline
Single intravenous injection of 120ml of normal saline over 30 minutes

Outcome Measures

Primary Outcome Measures :
  1. Degree of fatigue at the point of time with visual analogue scale from 0 to 10 [ Time Frame: Before intravenous vitamin C injection and right after completing injections, and one day later ]

Secondary Outcome Measures :
  1. Reactive oxygen species [ Time Frame: Before intravenous vitamin C injections, right after completing injections, and one day later ]
  2. Plasma vitamin C level [ Time Frame: Before intravenous vitamin C injections and right after completing injections ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 49 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Company workers working at least 5 days a week from morning to evening
  • Volunteers who provided written informed consent

Exclusion Criteria:

  • Acute illness
  • Chronic disease such as diabetes, hypertension, liver disease, or renal disease
  • Previous history of renal stone or gout
  • Pregnant or lactating women
  • Hypersensitivity to vitamins or intravenous injections
  • History of vitamin supplements orally or parenterally within 2 days
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00633581

Korea, Republic of
DongGuk University International Hospital
Goyang-si, Gyeonggi-do, Korea, Republic of, 410-773
Sponsors and Collaborators
DongGuk University
Korean Association For Vitamin Research
Principal Investigator: Chang H Yeom, MD, PhD KwanDong University Myungji Hospital
More Information


Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: ChangHwan Yeom, Kwandong University College of Medicine Myungji Hospital
ClinicalTrials.gov Identifier: NCT00633581     History of Changes
Other Study ID Numbers: DUIH 2008-1-1
First Posted: March 12, 2008    Key Record Dates
Last Update Posted: April 10, 2009
Last Verified: April 2009

Keywords provided by DongGuk University:
ascorbic acid
oxidative stress

Additional relevant MeSH terms:
Signs and Symptoms
Ascorbic Acid
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents