Pentoxifylline and Endometriosis (LETS1)

This study has been completed.
Information provided by:
Hospital Clinic of Barcelona Identifier:
First received: March 4, 2008
Last updated: March 10, 2008
Last verified: March 2008
To prove efficacy of an immunomodulator called pentoxifylline in the treatment of endometriosis in infertile patients undergoing laparoscopy surgery

Condition Intervention Phase
Endometriosis-Associated Infertility
Drug: pentoxifylline
Drug: placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Combined Laparoscopic Surgery and Pentoxifylline Therapy for Treatment of Endometriosis-Associated Infertility: A Preliminary Study

Resource links provided by NLM:

Further study details as provided by Hospital Clinic of Barcelona:

Primary Outcome Measures:
  • Pregnancy rate [ Time Frame: 6 months follow-up ] [ Designated as safety issue: No ]

Enrollment: 104
Study Start Date: October 2001
Study Completion Date: December 2006
Primary Completion Date: December 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1 Drug: pentoxifylline
800 mg daily for six months
Placebo Comparator: 2 Drug: placebo


Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Infertile patients having early endometriosis as the only factor of their infertility

Exclusion Criteria:

  • Previous treatment for endometriosis or patients having pelvic disorders in addition to endometriosis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00632697

Hospital Clinic
Barcelona, Spain, 08036
Sponsors and Collaborators
Hospital Clinic of Barcelona
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00632697     History of Changes
Other Study ID Numbers: LETS 
Study First Received: March 4, 2008
Last Updated: March 10, 2008
Health Authority: Spain: Comité Ético de Investigación Clínica

Keywords provided by Hospital Clinic of Barcelona:
laparoscopic surgery

Additional relevant MeSH terms:
Genital Diseases, Female
Genital Diseases, Male
Cardiovascular Agents
Enzyme Inhibitors
Free Radical Scavengers
Hematologic Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Phosphodiesterase Inhibitors
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Protective Agents
Radiation-Protective Agents
Therapeutic Uses
Vasodilator Agents processed this record on May 04, 2016