Breath Analysis by Ion Mobility Spectrometry

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2011 by Lung Clinic Hemer.
Recruitment status was  Recruiting
Information provided by:
Lung Clinic Hemer Identifier:
First received: February 29, 2008
Last updated: June 22, 2011
Last verified: May 2011

Recognition of disease specific clusters of volatile organic compounds in patients with different lung diseases, using breath analysis with ion mobility spectrometry. Lung diseases of interest are:

  • COPD
  • tumors
  • airway infection
  • interstitial lung disease
  • sleep apnea Hypothesis: Breath analysis with ion mobility spectrometry can differentiate pulmonary disorders.

Lung Diseases

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Detection of Clusters of Volatile Organic Compounds (VOC)in Patients With Different Lung Disorders by Ion Mobility Spectrometry. Different Clusters of VOC in the Diagnosis of Different Lung Disorders Using Ion Mobility Spectrometry

Resource links provided by NLM:

Further study details as provided by Lung Clinic Hemer:

Biospecimen Retention:   Samples Without DNA

breath, pleural fluid (only in patients with therapeutic pleurocentesis)

Estimated Enrollment: 1000
Study Start Date: July 2006
Estimated Study Completion Date: June 2015
Estimated Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
lung cancer
airway infection
interstitial lung disease
sleep apnea
pulmonary disorders with pleural infusions
healthy persons

Detailed Description:

Recruitment of patients with different lung diseases goes on. First sub-group analysis of patients with COPD,lung cancer and sarcoidosis is done in order to create a training set of VOC-clusters for further validation in a bigger population of patients.


Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients of the lung clinic hemer


Inclusion Criteria:

  • Any patient
  • Ages 18-90 years old
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00632307

Contact: Michael Westhoff, MD 004923729082203
Contact: Patric Litterst, MD 004923729082545

Lung Clinic Hemer Recruiting
Hemer, Germany, 58675
Contact: Michael Westhoff, MD    004923729082203   
Contact: Patric Litterst, MD    004923739082545   
Principal Investigator: Michael Westhoff, MD         
Sponsors and Collaborators
Lung Clinic Hemer
Principal Investigator: Michael Westhoff, MD Lung Clinic Hemer, 58675 Hemer, Germany
  More Information

Bunkowski A, Maddula S, Davies AN, Westhoff M, Litterst P, Bödeker B, Baumbach JI. One-year time series of investigations of analytes within human breath using ion mobility spectrometryInt. J. Ion Mobil. Spec. (2010) 13:141-148
Westhoff, M, Litterst P, Maddula S, Bödeker B, Rahman S, Davies AN, Baumbach JI. Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry. Int. J. Ion Mobil. Spec. (2010) 13:131-139
Vautz W. Baumbach JI, Westhoff M, Züchner, K, Carstens ETH, Perl T. Breath sampling control for medical application. Int. J. Ion Mobil. Spec. (2010) 13:41-46

Responsible Party: Michael Westhoff MD, Lung Clinic Hemer Identifier: NCT00632307     History of Changes
Other Study ID Numbers: lkhemer1-2008
Study First Received: February 29, 2008
Last Updated: June 22, 2011
Health Authority: Germany: Ethics Commission

Keywords provided by Lung Clinic Hemer:
lung tumor
pleural tumor
interstitial lung disease
airway infection
sleep apnea
ion mobility spectrometry
breath analysis

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases processed this record on August 30, 2015