Doxycycline for Lateral Epicondylalgia - RCT
Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.
This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.
Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
Please refer to this study by its ClinicalTrials.gov identifier: NCT00631501
|Contact: Alfredas Smailys, MD, PhD||+370 37 firstname.lastname@example.org|
|Dept of Orthopaedics, Kaunas Medical University||Recruiting|
|Contact: Alfredas Smailys email@example.com|