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Doxycycline for Lateral Epicondylalgia - RCT

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by Kaunas University of Medicine.
Recruitment status was:  Recruiting
University Hospital, Linkoeping
Information provided by:
Kaunas University of Medicine Identifier:
First received: February 27, 2008
Last updated: NA
Last verified: February 2008
History: No changes posted

Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.

This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.

Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.

Condition Intervention
Lateral Epicondylalgia (Tennis Elbow) Drug: Placebo Drug: Doxycycline

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Kaunas University of Medicine:

Primary Outcome Measures:
  • Pain (VAS)

Estimated Enrollment: 34
Arms Assigned Interventions
Placebo Comparator: 2 Drug: Placebo
Experimental: Doxycycline
100 mg twice daily
Drug: Doxycycline


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 18-65
  • Pain at the lateral side of the elbow ≥8 weeks
  • Local tenderness on palpation of the lateral epicondyle
  • Pain on resisted extension of the wrist

Exclusion Criteria:

  • Rheumatic disorder
  • History of fibromyalgia or generalised pain
  • Elbow surgery (on the painful side)
  • Active infection
  • Glucocorticoid treatment during the duration of symtoms of epicondylalgia
  • NSAID use within 1 w before presentation and during the study
  • Pregnancy
  • Taking drug that might interact with doxycycline
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00631501

Contact: Alfredas Smailys, MD, PhD +370 37 327201

Dept of Orthopaedics, Kaunas Medical University Recruiting
Kaunas, Lithuania
Contact: Alfredas Smailys   
Sponsors and Collaborators
Kaunas University of Medicine
University Hospital, Linkoeping
  More Information

Responsible Party: Per Aspenberg, Dept of Orthopaedics, University Hospital Linkoeping Identifier: NCT00631501     History of Changes
Other Study ID Numbers: BE-2-47
Study First Received: February 27, 2008
Last Updated: February 27, 2008

Keywords provided by Kaunas University of Medicine:
tennis elbow
lateral epicondylitis
lateral epicondylalgia

Additional relevant MeSH terms:
Tennis Elbow
Musculoskeletal Diseases
Arm Injuries
Wounds and Injuries
Anti-Bacterial Agents
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents processed this record on September 19, 2017