Doxycycline for Lateral Epicondylalgia - RCT

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00631501
Recruitment Status : Unknown
Verified February 2008 by Kaunas University of Medicine.
Recruitment status was:  Recruiting
First Posted : March 7, 2008
Last Update Posted : March 7, 2008
University Hospital, Linkoeping
Information provided by:
Kaunas University of Medicine

Brief Summary:

Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.

This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.

Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.

Condition or disease Intervention/treatment Phase
Lateral Epicondylalgia (Tennis Elbow) Drug: Placebo Drug: Doxycycline Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 34 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment

Arm Intervention/treatment
Placebo Comparator: 2 Drug: Placebo
Experimental: Doxycycline
100 mg twice daily
Drug: Doxycycline

Primary Outcome Measures :
  1. Pain (VAS)

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 18-65
  • Pain at the lateral side of the elbow ≥8 weeks
  • Local tenderness on palpation of the lateral epicondyle
  • Pain on resisted extension of the wrist

Exclusion Criteria:

  • Rheumatic disorder
  • History of fibromyalgia or generalised pain
  • Elbow surgery (on the painful side)
  • Active infection
  • Glucocorticoid treatment during the duration of symtoms of epicondylalgia
  • NSAID use within 1 w before presentation and during the study
  • Pregnancy
  • Taking drug that might interact with doxycycline

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00631501

Contact: Alfredas Smailys, MD, PhD +370 37 327201

Dept of Orthopaedics, Kaunas Medical University Recruiting
Kaunas, Lithuania
Contact: Alfredas Smailys   
Sponsors and Collaborators
Kaunas University of Medicine
University Hospital, Linkoeping

Responsible Party: Per Aspenberg, Dept of Orthopaedics, University Hospital Linkoeping Identifier: NCT00631501     History of Changes
Other Study ID Numbers: BE-2-47
First Posted: March 7, 2008    Key Record Dates
Last Update Posted: March 7, 2008
Last Verified: February 2008

Keywords provided by Kaunas University of Medicine:
tennis elbow
lateral epicondylitis
lateral epicondylalgia

Additional relevant MeSH terms:
Tennis Elbow
Elbow Tendinopathy
Muscular Diseases
Musculoskeletal Diseases
Arm Injuries
Wounds and Injuries
Tendon Injuries
Anti-Bacterial Agents
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents