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Effects of Cranberry Juice on Risk Factors for Cardiovascular Disease

This study has been completed.
Ocean Spray, Inc.
Information provided by:
Mayo Clinic Identifier:
First received: February 28, 2008
Last updated: August 10, 2011
Last verified: August 2011
This study is being done to determine if the use of double strength cranberry juice in daily diet will improve endothelial function.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effects of Cranberry Juice on Risk Factors for Cardiovascular Disease

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • The current study was designed to test the hypothesis that the chronic administration of supplementation with double-strength cranberry juice will improve peripheral endothelial dysfunction. [ Time Frame: baseline and 4 months post ]

Secondary Outcome Measures:
  • The current study was also designed to test the acute effect of double-strength cranberry juice on endothelial function. [ Time Frame: 45 mins post consumption ]

Biospecimen Retention:   Samples Without DNA

Estimated Enrollment: 60
Study Start Date: February 2008
Study Completion Date: December 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Bottle number 615
Patients are randomized to either Bottle number 615 or Bottle number 429 (actual product vs. placebo). This is a blinded study.
Bottle number 429
Patients are randomized to either Bottle number 615 or Bottle number 429 (actual product vs. placebo). This is a blinded study.

Detailed Description:
Study participants will be randomized assigned to drink either placebo (a drink that looks and tastes like cranberry juice, but does not contain cranberry juice) or a double strength Ocean Spray light cranberry juice cocktail for four months.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Mayo Clinic Patients

Inclusion Criteria:

  • Subjects over the age of 18 years old with known or suspected cardiovascular disease including documented CAD by cardiac catheterization, and multiple cardiovascular risk factors will be included, regardless of severity of endothelial dysfunction or previous history of cardiovascular events.
  • Subjects with no known history of cardiac disease will also be eligible to participate.
  • Subjects must demonstrate endothelial dysfunction via the RH-PAT test (an RH-PAT score of less than 2.0) to continue participating in this study.

Exclusion Criteria:

  • Patients will be excluded if they have confounding factors including, but not limited to, history of renal or liver failure, or relevant food allergies (cranberries, etc.).
  Contacts and Locations
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Please refer to this study by its identifier: NCT00631306

United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Ocean Spray, Inc.
Principal Investigator: Amir Lerman, MD Mayo Clinic
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Amir Lerman, MD, Mayo Clinic Identifier: NCT00631306     History of Changes
Other Study ID Numbers: 07-003443
Study First Received: February 28, 2008
Last Updated: August 10, 2011

Additional relevant MeSH terms:
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases processed this record on May 25, 2017