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Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00630071
First Posted: March 6, 2008
Last Update Posted: October 16, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Michael Sand, Ruhr University of Bochum
  Purpose
The values of laboratory examinations which are useful for the diagnoses of acute appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR). Another laboratory value which has recently received considerable attention for the early diagnosis of bacterial infection and sepsis is pro-calcitonin (PCT). In recent studies it has been clearly shown that PCT is one of the most important biochemical indicators which closely correlates with the severity of inflammatory host response to microbial infections. Aim of this open, prospective study is therefore to investigate if PCT has an accurate diagnostic value for the diagnosis of acute appendicitis.

Condition
Appendicitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Study Investigating the Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

Resource links provided by NLM:


Further study details as provided by Michael Sand, Ruhr University of Bochum:

Biospecimen Retention:   Samples With DNA
1.5 ml whole blood

Enrollment: 103
Study Start Date: February 2008
Study Completion Date: August 2008
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   14 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Surgical Emergency Room
Criteria

Inclusion Criteria:

  • Clinical diagnosis of appendicitis

Exclusion Criteria:

  • Antibiotic therapy
  • Infection at other body sites
  • Age < 14 years
  • Appendectomy in the medical history
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00630071


Locations
Germany
Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany
Bochum, Germany, 44791
Sponsors and Collaborators
Ruhr University of Bochum
Investigators
Study Chair: Benno Mann, PD Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
Principal Investigator: Michael Sand, Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
  More Information

Publications:
Responsible Party: Michael Sand, Dr., Ruhr University of Bochum
ClinicalTrials.gov Identifier: NCT00630071     History of Changes
Other Study ID Numbers: PCT 01
First Submitted: February 26, 2008
First Posted: March 6, 2008
Last Update Posted: October 16, 2012
Last Verified: October 2012

Keywords provided by Michael Sand, Ruhr University of Bochum:
Diagnostic Appendicitis
Procalcitonin

Additional relevant MeSH terms:
Appendicitis
Intraabdominal Infections
Infection
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Cecal Diseases
Intestinal Diseases
Calcitonin
Bone Density Conservation Agents
Physiological Effects of Drugs