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Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00630006
First Posted: March 6, 2008
Last Update Posted: March 6, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital
  Purpose
The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease

Condition Intervention
Hepatitis C Virus Infection Chronic Liver Disease Genetic: TNF-alpha and IL-10

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)

Resource links provided by NLM:


Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:
  • cytokine gene polymorphism on severity of disease [ Time Frame: years ]

Study Start Date: January 2007
Estimated Study Completion Date: December 2008
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Anti-HCV-positive patients

Exclusion Criteria:

  • Anti-HCV-negative patients
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00630006


Contacts
Contact: Jen-Eing Jeng, M.D. 886-7-3121101 ext 7223 jejeng@cc.kmu.edu.tw

Locations
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng @cc.kmu.edu.tw   
Principal Investigator: Jen-Eing Jeng, M.D.         
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng@cc.kmu.edu.tw   
Principal Investigator: Jen-Eing Jeng, M.D.         
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng@cc.kmu.edu.tw   
Principal Investigator: Jen-Eing Jeng, M,D,         
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Investigators
Principal Investigator: Jen-Eing Jeng, M.D. Assistant Professor
  More Information

ClinicalTrials.gov Identifier: NCT00630006     History of Changes
Other Study ID Numbers: KMUH-IRB-950182
First Submitted: February 26, 2008
First Posted: March 6, 2008
Last Update Posted: March 6, 2008
Last Verified: July 2007

Additional relevant MeSH terms:
Hepatitis C
Liver Diseases
Virus Diseases
Hepatitis, Viral, Human
Flaviviridae Infections
RNA Virus Infections
Hepatitis
Digestive System Diseases