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Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was:  Recruiting
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital Identifier:
First received: February 26, 2008
Last updated: March 5, 2008
Last verified: July 2007
The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease

Condition Intervention
Hepatitis C Virus Infection
Chronic Liver Disease
Genetic: TNF-alpha and IL-10

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label

Resource links provided by NLM:

Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:
  • cytokine gene polymorphism on severity of disease [ Time Frame: years ]

Study Start Date: January 2007
Estimated Study Completion Date: December 2008

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Anti-HCV-positive patients

Exclusion Criteria:

  • Anti-HCV-negative patients
  Contacts and Locations
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Please refer to this study by its identifier: NCT00630006

Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 807
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Principal Investigator: Jen-Eing Jeng, M.D. Assistant Professor
  More Information Identifier: NCT00630006     History of Changes
Other Study ID Numbers: KMUH-IRB-950182 
Study First Received: February 26, 2008
Last Updated: March 5, 2008

Additional relevant MeSH terms:
Hepatitis C
Liver Diseases
Virus Diseases
Hepatitis, Viral, Human
Flaviviridae Infections
RNA Virus Infections
Digestive System Diseases processed this record on February 20, 2017