Heart Valve Prosthesis-Patient Mismatch
The purpose of this study is to determine the frequency of prosthesis-patient mismatch after mitral valve replacement and its effect on clinical outcomes.
Heart Valve Diseases
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Impact of Prosthesis-Patient Mismatch on Clinical Outcomes After Mitral Valve Replacement|
|Study Start Date:||February 2008|
|Study Completion Date:||May 2008|
|Primary Completion Date:||May 2008 (Final data collection date for primary outcome measure)|
Patients with prosthesis-patient mismatch after mitral valve replacement
Patients without prosthesis mismatch after mitral valve replacement
Mitral valve replacement (MVR) is associated with higher short and long term mortality than aortic valve replacement or mitral valve repair. The suboptimal results of MVR underline the importance of identifying and preventing prosthesis- patient mismatch. The effective orifice area (EOA) of prosthetic valves used for MVR is often too small in relation to body size, thus causing a mismatch between valve EOA and transvalvular flow. As a consequence, normally functioning mitral prostheses often have relatively high gradients that are similar to those found in patients with mild to moderate mitral stenosis. Residual pressure gradients across mitral prostheses delay the regression of left atrial and pulmonary arterial hypertension. Pulmonary hypertension may cause rightsided failure and is an important risk factor for morbidity and mortality in patients with cardiovascular diseases. However data about the frequency of prosthesis-patient mismatch after mitral valve replacement and its effect on clinical outcome is inconclusive. Predetermined outcomes will be evaluated in the clinical course of this condition.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00629902
|T.C. Bilim University, Medical Faculty, Florence Nightingale Hospital, Division of Cardiology|
|Istanbul, Sisli, Turkey, 34381|
|Principal Investigator:||Saide Aytekin, Professor||T.C. Istanbul Bilim University, Medical Faculty, Florence Nightingale Hospital, Division of Cardiology|