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Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was:  Recruiting
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital Identifier:
First received: February 26, 2008
Last updated: March 5, 2008
Last verified: July 2007
The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.

Condition Intervention
Chronic Liver Disease
Hepatocellular Carcinoma
Genetic: TNF-alpha and HBV genotype
Other: TNF-alpha and HBV genotypes

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science

Resource links provided by NLM:

Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:
  • cytokine gene polymorohism on severity of disease [ Time Frame: years ]

Study Start Date: January 2007
Estimated Study Completion Date: December 2007

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • HBV-positive patients

Exclusion Criteria:

  • HBV-negative patients
  Contacts and Locations
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Please refer to this study by its identifier: NCT00629668

Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.    886-7-3121101 ext 7223    jejeng   
Principal Investigator: Jen-Eing Jeng, M.D.         
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Principal Investigator: Jen-Eing Jeng, M.D. Assistant Professor of Clinical Laboratory
  More Information Identifier: NCT00629668     History of Changes
Other Study ID Numbers: KMUH-IRB-940189
Study First Received: February 26, 2008
Last Updated: March 5, 2008

Additional relevant MeSH terms:
Carcinoma, Hepatocellular
Liver Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases processed this record on May 25, 2017