Genetic Polymorphysm of Cholesterol 24 S Hydroxylase in Patients With Glaucoma and AMD

This study has been completed.

Sponsor:

Information provided by:

Centre Hospitalier Universitaire Dijon

ClinicalTrials.gov Identifier:

NCT00629044

First received: February 25, 2008

Last updated: March 25, 2011

Last verified: August 2009

History of Changes

Purpose

The aim of this study is to assess the implicitement of the cholesterol 24 S hydroxylase gene and the 24 S hydroxycholesterol in glaucoma and in age related macular degeneration.

Condition	Intervention
Glaucoma	Biological: Assessing the blood level of cholesterol 24 S Hydroxylase Biological: Assessing the blood level of cholesterol 24 S hydroxylase Biological: assessing the blood level of cholesterol 24 S hydroxylase


Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Screening
Official Title:	Etude du Polymorphysme génétique de la cholestérol 24S Hydroxylase et Des Teneurs en 24S hydroxycholestérol Chez Des Patients Atteints de Glaucome ou de dégénérescence Maculaire liée à l'âge.

Resource links provided by NLM:

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Cholesterol Glaucoma

U.S. FDA Resources

Further study details as provided by Centre Hospitalier Universitaire Dijon:

Primary Outcome Measures:

To know if cholesterol 24 S hydroxylase and 24 hydroxycholesterol are involve in Glaucoma and AMD [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]


Estimated Enrollment:	320
Study Start Date:	November 2007
Study Completion Date:	January 2011
Primary Completion Date:	November 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Active Comparator: G	Biological: Assessing the blood level of cholesterol 24 S Hydroxylase Comparison of venous blood level of Cholesterol 24 S hydroxylase and 24 hydroxycholesterol in patients with Glaucoma and AMD and in healthy subjects.
Active Comparator: AMD	Biological: Assessing the blood level of cholesterol 24 S hydroxylase Comparison of venous blood level of cholesterol 24 S hydroxylase and 24 hydroxycholesterol in patients with Glaucoma, AMD end in healthy subjects
Active Comparator: Healthy subjects	Biological: assessing the blood level of cholesterol 24 S hydroxylase Comparison of venous blood level of cholesterol 24 S hydroxylase and 24 hydroxycholesterol in patients with glaucoma, AMD and in healthy subjects

Eligibility


Ages Eligible for Study:	40 Years and older (Adult, Senior)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patient with Glaucoma
Patient with AMD
Healthy patient

Exclusion Criteria:

All patients who use any treatment in order to maintain in normal value their blood cholesterol

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00629044

Locations


France
Ophthalmology Unit CHU Dijon
Dijon, Burgundy, France, 21000

Sponsors and Collaborators

Centre Hospitalier Universitaire Dijon

Investigators


Principal Investigator:	Catherine Creuzot-Gracher, MD, PhD	CHU Dijon

More Information

Publications:

Joffre C, Souchier M, Grégoire S, Viau S, Bretillon L, Acar N, Bron AM, Creuzot-Garcher C. Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye. Br J Ophthalmol. 2008 Jan;92(1):116-9.


Responsible Party:	Professor Catherine Creuzot-Garcher, CHU Dijon
ClinicalTrials.gov Identifier:	NCT00629044 History of Changes
Other Study ID Numbers:	PHRC IR 2006
Study First Received:	February 25, 2008
Last Updated:	March 25, 2011
Health Authority:	France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Additional relevant MeSH terms:


Glaucoma Ocular Hypertension Eye Diseases

ClinicalTrials.gov processed this record on September 23, 2016

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